Endothelial Nicotinic Acetylcholine Receptors and Angiogenesis

John P. Cooke, Yohannes T. Ghebremariam

Research output: Contribution to journalReview article

66 Scopus citations

Abstract

Nicotinic acetylcholine receptors (nAChRs) were first described in non-excitable cells just more than a decade ago. The nAChRs on endothelial cells modulate key angiogenic processes, including endothelial cell survival, proliferation, and migration. The receptors may be stimulated by endogenous agonists such as acetylcholine, or exogenous chemicals such as nicotine, to activate physiologic angiogenesis (such as in wound healing) or pathologic angiogenesis (such as retinal neovascularization or tumor angiogenesis). The endothelial nAChRs may represent a target for therapeutic modulation of disorders characterized by insufficient or pathologic angiogenesis.

Original languageEnglish (US)
Pages (from-to)247-253
Number of pages7
JournalTrends in Cardiovascular Medicine
Volume18
Issue number7
DOIs
StatePublished - Oct 2008

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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