Endothelial cells as therapeutic targets in cancer: New biology and novel delivery systems

J. C. Murray; S. M. Moghimi

doi:10.1615/CritRevTherDrugCarrierSyst.v20.i23.20

Endothelial cells as therapeutic targets in cancer: New biology and novel delivery systems

J. C. Murray, S. M. Moghimi

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

The significance of the endothelial cell as a target for antitumor therapy has been recognized for some time, but so far the results of clinical trials exploiting this approach have not been encouraging. The subject is likely to gain new momentum, however, following a number of important recent findings that shed new light on the origins and nature of tumor vasculature. Coupled with rapid developments in the use of phage-displayed peptide libraries to characterize the human vascular map, as well as highly selective delivery systems, this new understanding of tumor vascular biology should provide many fresh and exciting avenues to explore.

Original language	English (US)
Pages (from-to)	139-152
Number of pages	14
Journal	Critical Reviews in Therapeutic Drug Carrier Systems
Volume	20
Issue number	2-3
DOIs	https://doi.org/10.1615/CritRevTherDrugCarrierSyst.v20.i23.20
State	Published - 2003

Keywords

Antitumor therapy
Drug delivery systems
Human vascular map
Integrins
Peptidomimetics
Phage-display technology
Tumor neovasculature

ASJC Scopus subject areas

Pharmacology

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10.1615/CritRevTherDrugCarrierSyst.v20.i23.20

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title = "Endothelial cells as therapeutic targets in cancer: New biology and novel delivery systems",

abstract = "The significance of the endothelial cell as a target for antitumor therapy has been recognized for some time, but so far the results of clinical trials exploiting this approach have not been encouraging. The subject is likely to gain new momentum, however, following a number of important recent findings that shed new light on the origins and nature of tumor vasculature. Coupled with rapid developments in the use of phage-displayed peptide libraries to characterize the human vascular map, as well as highly selective delivery systems, this new understanding of tumor vascular biology should provide many fresh and exciting avenues to explore.",

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KW - Integrins

KW - Peptidomimetics

KW - Phage-display technology

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Endothelial cells as therapeutic targets in cancer: New biology and novel delivery systems

Abstract

Keywords

ASJC Scopus subject areas

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