Endothelial cells as therapeutic targets in cancer: New biology and novel delivery systems

J. C. Murray, S. M. Moghimi

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

The significance of the endothelial cell as a target for antitumor therapy has been recognized for some time, but so far the results of clinical trials exploiting this approach have not been encouraging. The subject is likely to gain new momentum, however, following a number of important recent findings that shed new light on the origins and nature of tumor vasculature. Coupled with rapid developments in the use of phage-displayed peptide libraries to characterize the human vascular map, as well as highly selective delivery systems, this new understanding of tumor vascular biology should provide many fresh and exciting avenues to explore.

Original languageEnglish (US)
Pages (from-to)139-152
Number of pages14
JournalCritical Reviews in Therapeutic Drug Carrier Systems
Volume20
Issue number2-3
DOIs
StatePublished - 2003

Keywords

  • Antitumor therapy
  • Drug delivery systems
  • Human vascular map
  • Integrins
  • Peptidomimetics
  • Phage-display technology
  • Tumor neovasculature

ASJC Scopus subject areas

  • Pharmacology

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