Endoproteolysis of presenilin in vitro: Inhibition by γ-secretase inhibitors

Keyphrases

• Presenilin 100%
• γ-secretase Inhibitor 100%
• In Vitro Inhibition 100%
• Endoproteolysis 100%
• Alzheimer's Disease 42%
• Enriched Fractions 28%
• Disease-causing mutations 28%
• Potent Inhibitor 14%
• Transition State Analogue 14%
• Mammalian Cells 14%
• Membrane Protein 14%
• Endoplasmic Reticulum 14%
• Amyloidogenic 14%
• Amyloid Precursor Protein 14%
• Secretase 14%
• Protease 14%
• Membrane Vesicles 14%
• Cytosolic Proteins 14%
• Cell-free System 14%
• Golgi 14%
• Amyloid Protein 14%
• Production Increase 14%
• Integral Membrane Protein 14%
• C-terminal Fragments 14%
• N-terminal Fragment 14%
• Pepstatin A 14%
• Trans-Golgi Network 14%
• Biochemical Approaches 14%
• Peripheral Membrane 14%
• General Inhibitor 14%
• Functional Complexity 14%

Neuroscience

• In Vitro 100%
• Secretase 100%
• Presenilin 100%
• Alzheimer's Disease 42%
• C-Terminus 14%
• Amino Terminal Sequence 14%
• Amyloid Precursor Protein 14%
• Proteinase 14%
• Endoplasmic Reticulum 14%
• Amyloid A Protein 14%
• Membrane Vesicle 14%
• Integral Membrane Protein 14%
• Pepstatin 14%

Biochemistry, Genetics and Molecular Biology

• Presenilin 100%
• Secretase 100%
• Enzyme 14%
• C-Terminus 14%
• N-Terminus 14%
• Transition State Analog 14%
• Amyloid Protein 14%
• Amyloid Precursor Protein 14%
• Protease 14%
• Cell-Free System 14%
• Membrane Vesicle 14%
• Integral Membrane Protein 14%
• Pepstatin 14%