Endogenous regulators of NO bioavailability in rats with acute renal failure

R. A. Sukhovershin; M. A. Gilinsky

doi:10.1007/s10517-012-1736-2

Endogenous regulators of NO bioavailability in rats with acute renal failure

R. A. Sukhovershin, M. A. Gilinsky

Research output: Contribution to journal › Article › peer-review

Abstract

We studied the impact of acute glycerol-induced renal failure on blood levels and daily urinary excretion of arginine, monomethylarginine, and asymmetric and symmetric dimethylarginine. Acute renal failure was accompanied by enhanced daily excretion of asymmetric and symmetric dimethylarginine, increased plasma level of symmetric dimethylarginine, and decreased plasma level of arginine. Reabsorption of arginine and its methylated analogues decreased, thus compensating for reduced glomerular filtration rate. These data attest to increased production of dimethylarginines during acute renal failure. These changes can decrease NO bioavailability.

Original language	English (US)
Pages (from-to)	444-447
Number of pages	4
Journal	Bulletin of Experimental Biology and Medicine
Volume	153
Issue number	4
DOIs	https://doi.org/10.1007/s10517-012-1736-2
State	Published - Aug 2012

Keywords

Arginine
Methylarginine
Nitric oxide
Renal failure

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1007/s10517-012-1736-2

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AB - We studied the impact of acute glycerol-induced renal failure on blood levels and daily urinary excretion of arginine, monomethylarginine, and asymmetric and symmetric dimethylarginine. Acute renal failure was accompanied by enhanced daily excretion of asymmetric and symmetric dimethylarginine, increased plasma level of symmetric dimethylarginine, and decreased plasma level of arginine. Reabsorption of arginine and its methylated analogues decreased, thus compensating for reduced glomerular filtration rate. These data attest to increased production of dimethylarginines during acute renal failure. These changes can decrease NO bioavailability.

KW - Arginine

KW - Methylarginine

KW - Nitric oxide

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Endogenous regulators of NO bioavailability in rats with acute renal failure

Abstract

Keywords

ASJC Scopus subject areas

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