TY - JOUR
T1 - Endogenous fungal endophthalmitis
T2 - Causative organisms, management strategies, and visual acuity outcomes
AU - Lingappan, Ahila
AU - Wykoff, Charles C.
AU - Albini, Thomas A.
AU - Miller, Darlene
AU - Pathengay, Avinash
AU - Davis, Janet L.
AU - Flynn, Harry W.
N1 - Funding Information:
Publication of this article was supported by grant P30-EY014801 from the National Institutes of Health , Bethesda, Maryland; an unrestricted grant to the University of Miami from Research to Prevent Blindness, Inc , New York, New York; and the Heed Ophthalmic Foundation, Cleveland, Ohio (C.C.W.). Dr Albini is a consultant to Alcon, Allergan, and Bausch & Lomb (TAA); Dr Flynn is a consultant to Alcon, Allergan, Pfizer, and Santen. Dr Davis is a consultant to Novartis and Centocor and receives financial support from Santen. Involved in Design and conduct of study (A.L., C.C.W., T.A.A., D.M., H.W.F.); Collection (A.L., C.C.W.), management (A.L., C.C.W.), analysis (A.L., T.A.A., A.P.), and interpretation (A.L., C.C.W., T.A.A., A.P., D.M., H.W.F.) of data; and Preparation (A.L., T.A.A., A.P.), review (J.L.D., H.W.F.), or approval (A.L., C.C.W., T.A.A., A.P., D.M., J.L.D., H.W.F.) of the manuscript. Institutional Review Board (IRB) approval was obtained for this retrospective study at the University of Miami (protocol 20061106), and the study was in compliance with IRB regulations and the Health Insurance Portability and Accountability Act of 1996.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2012/1
Y1 - 2012/1
N2 - To report the causative organisms, management strategies, and visual outcomes in endogenous fungal endophthalmitis. Observational case series. Microbiologic and medical records were reviewed retrospectively for all patients with culture-positive endogenous fungal endophthalmitis between January 1, 1990, and July 1, 2009. Study criteria were met in 65 eyes of 51 patients with mean follow-up of 18 months. Yeasts were the most common causative organism in 38 (75%) patients compared with molds in 13 (25%) patients. Retinal detachment occurred in 17 eyes (26%). Visual acuity of 20/200 or better was present in 28 (56%) eyes with yeasts and in 5 (33%) eyes with molds at the last follow-up. Yeasts were the most common cause of culture-proven unilateral or bilateral endogenous fungal endophthalmitis. Endogenous fungal endophthalmitis generally is associated with poor visual acuity outcomes, especially when caused by molds. Retinal detachment is a frequent occurrence during follow-up.
AB - To report the causative organisms, management strategies, and visual outcomes in endogenous fungal endophthalmitis. Observational case series. Microbiologic and medical records were reviewed retrospectively for all patients with culture-positive endogenous fungal endophthalmitis between January 1, 1990, and July 1, 2009. Study criteria were met in 65 eyes of 51 patients with mean follow-up of 18 months. Yeasts were the most common causative organism in 38 (75%) patients compared with molds in 13 (25%) patients. Retinal detachment occurred in 17 eyes (26%). Visual acuity of 20/200 or better was present in 28 (56%) eyes with yeasts and in 5 (33%) eyes with molds at the last follow-up. Yeasts were the most common cause of culture-proven unilateral or bilateral endogenous fungal endophthalmitis. Endogenous fungal endophthalmitis generally is associated with poor visual acuity outcomes, especially when caused by molds. Retinal detachment is a frequent occurrence during follow-up.
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U2 - 10.1016/j.ajo.2011.06.020
DO - 10.1016/j.ajo.2011.06.020
M3 - Article
C2 - 21917234
AN - SCOPUS:83555176157
SN - 0002-9394
VL - 153
SP - 162-166.e1
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 1
ER -