Endocrine disruptors targeting ERβ function

E. Swedenborg, I. Pongratz, J. Å Gustafsson

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Endocrine disruptive chemicals (EDCs) circulating in the environment constitute a risk to ecosystems, wildlife and human health. Oestrogen receptor (ER) alpha and beta are targeted by various kinds of EDCs but the molecular mechanisms and long-term consequences of exposure are largely unknown. Some biological effects of EDCs are mediated by the aryl hydrocarbon receptor (AhR), which is a key player in the cellular defence against xenobiotic substances. Adding complexity to the picture, there is also accumulating evidence that AhR-ER pathways have an intricate interplay at multiple levels. In this review, we discuss some EDCs that affect the oestrogen pathway by targeting ERβ. Furthermore, we describe some effects of AhR activities on the oestrogen system. Mechanisms as well as potential adverse effects on human health are discussed.

Original languageEnglish (US)
Pages (from-to)288-297
Number of pages10
JournalInternational Journal of Andrology
Volume33
Issue number2
DOIs
StatePublished - Apr 2010

Keywords

  • 2,3,7,8-tetrachlorodibenzo-p-dioxin
  • 3-methylcholanthrene
  • ARNT
  • Aryl hydrocarbon receptor
  • Endocrine disruption
  • Metabolism
  • Oestrogen receptor beta

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Urology

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