Encouraging initial response of restless legs syndrome to pramipexole

Philip M. Becker, William Ondo, Denise Sharon

Research output: Contribution to journalArticlepeer-review

69 Scopus citations


Restless legs syndrome (RLS) is a common condition that results in uncomfortable sensations and an urge to move the limbs. Two centers tested a new dopamine agonist, pramipexole, in 23 patients with RLS in a time-limited, open-label, clinical trial. After 4 weeks or more, 19 patients reported significant improvement as assessed by the short International Restless Legs Syndrome Study Group questionnaire (p < 0.0001). These encouraging preliminary results justify larger, controlled trials for pramipexole in patients with RLS.

Original languageEnglish (US)
Pages (from-to)1221-1223
Number of pages3
Issue number4
StatePublished - Oct 1998

ASJC Scopus subject areas

  • Clinical Neurology


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