Encapsulation of Fe3O4 in gelatin nanoparticles: Effect of different parameters on size and stability of the colloidal dispersion

Babita Gaihre, Santosh Aryal, Myung Seob Khil, Hak Yong Kim

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Encapsulation of magnetite (IOPs) in gelatin nanoparticles has been carried out by in situ precipitation of the particles in presence of gelatin, followed by desolvation and cross-linking of the composite nanoparticles. The aim of the study was to investigate the effect of various formulation parameters (viz; desolvating agent, cross-linking agent and percentage of IOPs) on the hydrodynamic size of the gelatin-coated magnetic iron oxide composite nanoparticles (GIOPs) and stability of the colloidal dispersion. Extensive characterization by dynamic light scattering, thermogravimetric analysis, X-ray diffraction, infrared spectroscopy, transmission electron microscopy and atomic force microscopy shows complete encapsulation of IOPs of size below 8 nm into gelatin nanoparticles of varying size. Size as well as stability of the colloidal dispersion of the GIOPs was found to be dependent on the investigated parameters. Furthermore, the nanoparticle dispersion was found to be stable in pH ranges from 2-12. Thus, obtained composite nanoparticles could hold promise as a carrier system in biomedical applications.

Original languageEnglish (US)
Pages (from-to)21-30
Number of pages10
JournalJournal of Microencapsulation
Volume25
Issue number1
DOIs
StatePublished - Feb 2008

Keywords

  • Colloidal dispersion
  • Composite nanoparticle
  • Cross-linking agent
  • Desolvating agent
  • Encapsulation
  • Magnetite

ASJC Scopus subject areas

  • Chemistry (miscellaneous)
  • Pharmaceutical Science
  • Chemical Engineering(all)
  • Pharmacology

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