EMT process in bone metastasis

Dingcheng Gao; Xiang H.F. Zhang; Erik W. Thompson; Vivek Mittal

doi:10.1016/B978-0-12-821666-8.00009-8

EMT process in bone metastasis

Dingcheng Gao, Xiang H.F. Zhang, Erik W. Thompson, Vivek Mittal

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Epithelial to mesenchymal transition (EMT), an evolutionary conserved developmental program has been implicated in carcinogenesis, as EMT confers metastatic properties upon cancer cells by enhancing mobility, invasion, and resistance to apoptotic stimuli. Therefore, targeting EMT pathways constitute an attractive strategy for cancer treatment. However, challenges in accurately tracking dynamic epithelial-mesenchymal transitions as a function of the metastatic cascade has yielded conflicting results, and therefore determining the functional role of EMT in metastasis remains an area of active investigation. This chapter will focus on EMT in cancer progression, with emphasis on bone metastases, and discusses opportunities for novel anti-metastatic approaches for cancer therapy.

Original language	English (US)
Title of host publication	Bone Cancer
Subtitle of host publication	Bone Sarcomas and Bone Metastases - From Bench to Bedside
Publisher	Elsevier
Pages	359-370
Number of pages	12
ISBN (Electronic)	9780128216668
DOIs	https://doi.org/10.1016/B978-0-12-821666-8.00009-8
State	Published - Jan 1 2021

Keywords

Bone metastasis
Epithelial-mesenchymal transition
Niche
Plasticity
Stem cell
Therapy

ASJC Scopus subject areas

Medicine(all)

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10.1016/B978-0-12-821666-8.00009-8

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title = "EMT process in bone metastasis",

abstract = "Epithelial to mesenchymal transition (EMT), an evolutionary conserved developmental program has been implicated in carcinogenesis, as EMT confers metastatic properties upon cancer cells by enhancing mobility, invasion, and resistance to apoptotic stimuli. Therefore, targeting EMT pathways constitute an attractive strategy for cancer treatment. However, challenges in accurately tracking dynamic epithelial-mesenchymal transitions as a function of the metastatic cascade has yielded conflicting results, and therefore determining the functional role of EMT in metastasis remains an area of active investigation. This chapter will focus on EMT in cancer progression, with emphasis on bone metastases, and discusses opportunities for novel anti-metastatic approaches for cancer therapy.",

keywords = "Bone metastasis, Epithelial-mesenchymal transition, Niche, Plasticity, Stem cell, Therapy",

author = "Dingcheng Gao and Zhang, {Xiang H.F.} and Thompson, {Erik W.} and Vivek Mittal",

year = "2021",

month = jan,

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doi = "10.1016/B978-0-12-821666-8.00009-8",

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T1 - EMT process in bone metastasis

AU - Gao, Dingcheng

AU - Zhang, Xiang H.F.

AU - Thompson, Erik W.

AU - Mittal, Vivek

PY - 2021/1/1

Y1 - 2021/1/1

N2 - Epithelial to mesenchymal transition (EMT), an evolutionary conserved developmental program has been implicated in carcinogenesis, as EMT confers metastatic properties upon cancer cells by enhancing mobility, invasion, and resistance to apoptotic stimuli. Therefore, targeting EMT pathways constitute an attractive strategy for cancer treatment. However, challenges in accurately tracking dynamic epithelial-mesenchymal transitions as a function of the metastatic cascade has yielded conflicting results, and therefore determining the functional role of EMT in metastasis remains an area of active investigation. This chapter will focus on EMT in cancer progression, with emphasis on bone metastases, and discusses opportunities for novel anti-metastatic approaches for cancer therapy.

AB - Epithelial to mesenchymal transition (EMT), an evolutionary conserved developmental program has been implicated in carcinogenesis, as EMT confers metastatic properties upon cancer cells by enhancing mobility, invasion, and resistance to apoptotic stimuli. Therefore, targeting EMT pathways constitute an attractive strategy for cancer treatment. However, challenges in accurately tracking dynamic epithelial-mesenchymal transitions as a function of the metastatic cascade has yielded conflicting results, and therefore determining the functional role of EMT in metastasis remains an area of active investigation. This chapter will focus on EMT in cancer progression, with emphasis on bone metastases, and discusses opportunities for novel anti-metastatic approaches for cancer therapy.

KW - Bone metastasis

KW - Epithelial-mesenchymal transition

KW - Niche

KW - Plasticity

KW - Stem cell

KW - Therapy

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DO - 10.1016/B978-0-12-821666-8.00009-8

M3 - Chapter

AN - SCOPUS:85126785067

SP - 359

EP - 370

BT - Bone Cancer

PB - Elsevier

ER -

EMT process in bone metastasis

Abstract

Keywords

ASJC Scopus subject areas

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