Emerging immunomodulatory strategies for cell therapeutics

Corrine Ying Xuan Chua, Allen Yujie Jiang, Tatiane Eufrásio-da-Silva, Alireza Dolatshahi-Pirouz, Robert Langer, Gorka Orive, Alessandro Grattoni

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Cellular therapies are poised to transform the field of medicine by restoring dysfunctional tissues and treating various diseases in a dynamic manner not achievable by conventional pharmaceutics. Spanning various therapeutic areas inclusive of cancer, regenerative medicine, and immune disorders, cellular therapies comprise stem or non-stem cells derived from various sources. Despite numerous clinical approvals or trials underway, the host immune response presents a critical impediment to the widespread adoption and success of cellular therapies. Here, we review current research and clinical advances in immunomodulatory strategies to mitigate immune rejection or promote immune tolerance to cellular therapies. We discuss the potential of these immunomodulatory interventions to accelerate translation or maximize the prospects of improving therapeutic outcomes of cellular therapies for clinical success.

Original languageEnglish (US)
Pages (from-to)358-373
Number of pages16
JournalTrends in Biotechnology
Volume41
Issue number3
Early online dateDec 20 2022
DOIs
StatePublished - Mar 2023

Keywords

  • cell transplantation
  • cellular therapy
  • immune modulation
  • immunosuppression

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

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