Emerging immunomodulatory strategies for cell therapeutics

Corrine Ying Xuan Chua, Allen Yujie Jiang, Tatiane Eufrásio-da-Silva, Alireza Dolatshahi-Pirouz, Robert Langer, Gorka Orive, Alessandro Grattoni

Research output: Contribution to journalReview articlepeer-review

Abstract

Cellular therapies are poised to transform the field of medicine by restoring dysfunctional tissues and treating various diseases in a dynamic manner not achievable by conventional pharmaceutics. Spanning various therapeutic areas inclusive of cancer, regenerative medicine, and immune disorders, cellular therapies comprise stem or non-stem cells derived from various sources. Despite numerous clinical approvals or trials underway, the host immune response presents a critical impediment to the widespread adoption and success of cellular therapies. Here, we review current research and clinical advances in immunomodulatory strategies to mitigate immune rejection or promote immune tolerance to cellular therapies. We discuss the potential of these immunomodulatory interventions to accelerate translation or maximize the prospects of improving therapeutic outcomes of cellular therapies for clinical success.

Original languageEnglish (US)
JournalTrends in Biotechnology
DOIs
StateE-pub ahead of print - Dec 20 2022

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