Emerging Challenges to Cellular Therapy of Cancer

Premal D. Lulla, Malcolm Brenner

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Cellular immunotherapy of cancer in the form of chimeric antigen receptor-modified T-cell therapy has become a standard treatment for lymphoid and more recently plasma cell malignancies. Although their successes in these cancers represent a breakthrough for adoptive cell therapy, there are several challenges to their continued growth in the field of cancer medicine. In this review, we discuss the progress made thus far toward achieving "off-the-shelf"accessibility of cell therapies that has the potential to greatly offset the costs associated with the current practice of making patient-specific products. We also review the innovations under investigation that attempt to make cellular therapy applicable to solid tumors as well.

Original languageEnglish (US)
Pages (from-to)20-27
Number of pages8
JournalCancer Journal (United States)
Issue number1
StatePublished - Jan 1 2023


  • Adoptive cell therapy
  • cellular immunotherapy
  • chimeric antigen receptor-T-cell therapy
  • lymphoid malignancies
  • multiple myeloma
  • off-the-shelf cell therapy
  • Neoplasms/therapy
  • T-Lymphocytes
  • Immunotherapy, Adoptive
  • Humans
  • Immunotherapy
  • Cell- and Tissue-Based Therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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