Emergence of serotype IV group B streptococcus adult invasive disease in Manitoba and saskatchewan, Canada, is driven by clonal sequence type 459 strains

Sarah Teatero, Taryn B.T. Athey, Paul Van Caeseele, Greg Horsman, David C. Alexander, Roberto G. Melano, Aimin Li, Anthony R. Flores, Samuel A. Shelburne, Allison McGeer, Walter Demczuk, Irene Martin, Nahuel Fittipaldi

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Serotype IV group B Streptococcus (GBS) is emerging in Canada and the United States with rates as high as 5% of the total burden of adult invasive GBS disease. To understand this emergence, we studied the population structure and assessed the antimicrobial susceptibility of serotype IV isolates causing adult invasive infection in Manitoba and Saskatchewan, Canada, between 2010 and 2014. Whole-genome sequencing was used to determine multilocus sequence typing information and identify genes encoding antimicrobial resistance in 85 invasive serotype IV GBS strains. Antimicrobial susceptibility testing was performed by standard methods. Strain divergence was assessed using genome-wide single-nucleotide polymorphism analysis. Serotype IV strains were responsible for 16.9% of adult invasive GBS infections in Manitoba and Saskatchewan during the period. The majority of serotype IV isolates (89%) were clonally related, tetracycline-, erythromycin-, and clindamycin-resistant sequence type 459 (ST459) strains that possessed genes tetM and ermTR. Genome comparisons between ST459 and serotype V ST1 GBS identified several areas of recombination in an overall similar genomic background. Serotype IV ST459 GBS strains are expanding and causing a substantial percentage of adult invasive GBS disease. This emergence may be linked to the acquisition of resistance to tetracycline, macrolides, and lincosamides.

Original languageEnglish (US)
Pages (from-to)2919-2926
Number of pages8
JournalJournal of Clinical Microbiology
Volume53
Issue number9
DOIs
StatePublished - Sep 1 2015

ASJC Scopus subject areas

  • Microbiology (medical)

Fingerprint Dive into the research topics of 'Emergence of serotype IV group B streptococcus adult invasive disease in Manitoba and saskatchewan, Canada, is driven by clonal sequence type 459 strains'. Together they form a unique fingerprint.

Cite this