Emergence of a Streptococcus pneumoniae clinical isolate highly resistant to telithromycin and fluoroquinolones

Diego Faccone; Patricia Andres; Marcelo Galas; Marta Tokumoto; Adriana Rosato; Alejandra Corso

doi:10.1128/JCM.43.11.5800-5803.2005

Emergence of a Streptococcus pneumoniae clinical isolate highly resistant to telithromycin and fluoroquinolones

Diego Faccone, Patricia Andres, Marcelo Galas, Marta Tokumoto, Adriana Rosato, Alejandra Corso

Academic Institute

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Streptococcus pneumoniae is a major pathogen causing community-acquired pneumonia and acute bronchitis. Macrolides, fluoroquinolones (FQs), and, recently, telithromycin (TEL) constitute primary therapeutic options, and rare cases of resistance have been reported. In this report, we describe the emergence of an 5. pneumoniae clinical isolate with high-level TEL resistance (MIC, 256 μg/ml) and simultaneous resistance to FQs. Ongoing studies are oriented to elucidate the precise mechanism of resistance to TEL.

Original language	English (US)
Pages (from-to)	5800-5803
Number of pages	4
Journal	Journal of Clinical Microbiology
Volume	43
Issue number	11
DOIs	https://doi.org/10.1128/JCM.43.11.5800-5803.2005
State	Published - Nov 2005

ASJC Scopus subject areas

Microbiology (medical)

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abstract = "Streptococcus pneumoniae is a major pathogen causing community-acquired pneumonia and acute bronchitis. Macrolides, fluoroquinolones (FQs), and, recently, telithromycin (TEL) constitute primary therapeutic options, and rare cases of resistance have been reported. In this report, we describe the emergence of an 5. pneumoniae clinical isolate with high-level TEL resistance (MIC, 256 μg/ml) and simultaneous resistance to FQs. Ongoing studies are oriented to elucidate the precise mechanism of resistance to TEL.",

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AU - Faccone, Diego

AU - Andres, Patricia

AU - Galas, Marcelo

AU - Tokumoto, Marta

AU - Rosato, Adriana

AU - Corso, Alejandra

PY - 2005/11

Y1 - 2005/11

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AB - Streptococcus pneumoniae is a major pathogen causing community-acquired pneumonia and acute bronchitis. Macrolides, fluoroquinolones (FQs), and, recently, telithromycin (TEL) constitute primary therapeutic options, and rare cases of resistance have been reported. In this report, we describe the emergence of an 5. pneumoniae clinical isolate with high-level TEL resistance (MIC, 256 μg/ml) and simultaneous resistance to FQs. Ongoing studies are oriented to elucidate the precise mechanism of resistance to TEL.

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Emergence of a Streptococcus pneumoniae clinical isolate highly resistant to telithromycin and fluoroquinolones

Abstract

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