Emergence of a Streptococcus pneumoniae clinical isolate highly resistant to telithromycin and fluoroquinolones

Diego Faccone, Patricia Andres, Marcelo Galas, Marta Tokumoto, Adriana Rosato, Alejandra Corso

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Streptococcus pneumoniae is a major pathogen causing community-acquired pneumonia and acute bronchitis. Macrolides, fluoroquinolones (FQs), and, recently, telithromycin (TEL) constitute primary therapeutic options, and rare cases of resistance have been reported. In this report, we describe the emergence of an 5. pneumoniae clinical isolate with high-level TEL resistance (MIC, 256 μg/ml) and simultaneous resistance to FQs. Ongoing studies are oriented to elucidate the precise mechanism of resistance to TEL.

Original languageEnglish (US)
Pages (from-to)5800-5803
Number of pages4
JournalJournal of Clinical Microbiology
Volume43
Issue number11
DOIs
StatePublished - Nov 2005

ASJC Scopus subject areas

  • Microbiology (medical)

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