TY - JOUR
T1 - Emergence of a Streptococcus pneumoniae clinical isolate highly resistant to telithromycin and fluoroquinolones
AU - Faccone, Diego
AU - Andres, Patricia
AU - Galas, Marcelo
AU - Tokumoto, Marta
AU - Rosato, Adriana
AU - Corso, Alejandra
PY - 2005/11
Y1 - 2005/11
N2 - Streptococcus pneumoniae is a major pathogen causing community-acquired pneumonia and acute bronchitis. Macrolides, fluoroquinolones (FQs), and, recently, telithromycin (TEL) constitute primary therapeutic options, and rare cases of resistance have been reported. In this report, we describe the emergence of an 5. pneumoniae clinical isolate with high-level TEL resistance (MIC, 256 μg/ml) and simultaneous resistance to FQs. Ongoing studies are oriented to elucidate the precise mechanism of resistance to TEL.
AB - Streptococcus pneumoniae is a major pathogen causing community-acquired pneumonia and acute bronchitis. Macrolides, fluoroquinolones (FQs), and, recently, telithromycin (TEL) constitute primary therapeutic options, and rare cases of resistance have been reported. In this report, we describe the emergence of an 5. pneumoniae clinical isolate with high-level TEL resistance (MIC, 256 μg/ml) and simultaneous resistance to FQs. Ongoing studies are oriented to elucidate the precise mechanism of resistance to TEL.
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U2 - 10.1128/JCM.43.11.5800-5803.2005
DO - 10.1128/JCM.43.11.5800-5803.2005
M3 - Article
C2 - 16272525
AN - SCOPUS:27744440428
SN - 0095-1137
VL - 43
SP - 5800
EP - 5803
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
IS - 11
ER -