Elucidation of estrogen receptor function in bone with the use of mouse models

Sara H. Windahl, Göran Andersson, Jan-Ake Gustafsson

Research output: Contribution to journalReview article

82 Scopus citations

Abstract

Since the discovery that estrogen receptors (ERs) are present in bone cells, there has been intense research into the action of estrogen in bone. During the past decade, humans with disturbed estrogen signaling, either as a result of ERα or aromatase deficiency, have been reported. Furthermore, mouse models have been established with a deficiency of ERα, ERβ or both, in addition to deficiency of aromatase. This review focuses on data accumulated during the past three years from studies of knockout mice with impaired estrogen signaling resulting from ER or aromatase deficiency.

Original languageEnglish (US)
Pages (from-to)195-200
Number of pages6
JournalTrends in Endocrinology and Metabolism
Volume13
Issue number5
DOIs
StatePublished - Jul 1 2002

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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