Elucidation of a Novel Pathway through Which HDAC1 Controls Cardiomyocyte Differentiation through Expression of SOX-17 and BMP2

Eneda Hoxha; Erin Lambers; John A. Wasserstrom; Alexander Mackie; Veronica Ramirez; Tatiana Abramova; Suresh K. Verma; Prasanna Krishnamurthy; Raj Kishore

doi:10.1371/journal.pone.0045046

Elucidation of a Novel Pathway through Which HDAC1 Controls Cardiomyocyte Differentiation through Expression of SOX-17 and BMP2

Eneda Hoxha, Erin Lambers, John A. Wasserstrom, Alexander Mackie, Veronica Ramirez, Tatiana Abramova, Suresh K. Verma, Prasanna Krishnamurthy, Raj Kishore

Academic Institute

Research output: Contribution to journal › Article

8 Scopus citations

Abstract

Embryonic Stem Cells not only hold a lot of potential for use in regenerative medicine, but also provide an elegant and efficient way to study specific developmental processes and pathways in mammals when whole animal gene knock out experiments fail. We have investigated a pathway through which HDAC1 affects cardiovascular and more specifically cardiomyocyte differentiation in ES cells by controlling expression of SOX17 and BMP2 during early differentiation. This data explains current discrepancies in the role of HDAC1 in cardiovascular differentiation and sheds light into a new pathway through which ES cells determine cardiovascular cell fate.

Original language	English (US)
Article number	e45046
Journal	PLoS ONE
Volume	7
Issue number	9
DOIs	https://doi.org/10.1371/journal.pone.0045046
State	Published - Sep 12 2012

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)
General

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Elucidation of a Novel Pathway through Which HDAC1 Controls Cardiomyocyte Differentiation through Expression of SOX-17 and BMP2. / Hoxha, Eneda; Lambers, Erin; Wasserstrom, John A.; Mackie, Alexander; Ramirez, Veronica; Abramova, Tatiana; Verma, Suresh K.; Krishnamurthy, Prasanna; Kishore, Raj.

In: PLoS ONE, Vol. 7, No. 9, e45046, 12.09.2012.

Research output: Contribution to journal › Article

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