TY - JOUR
T1 - Elucidation of a Novel Pathway through Which HDAC1 Controls Cardiomyocyte Differentiation through Expression of SOX-17 and BMP2
AU - Hoxha, Eneda
AU - Lambers, Erin
AU - Wasserstrom, John A.
AU - Mackie, Alexander
AU - Ramirez, Veronica
AU - Abramova, Tatiana
AU - Verma, Suresh K.
AU - Krishnamurthy, Prasanna
AU - Kishore, Raj
PY - 2012/9/12
Y1 - 2012/9/12
N2 - Embryonic Stem Cells not only hold a lot of potential for use in regenerative medicine, but also provide an elegant and efficient way to study specific developmental processes and pathways in mammals when whole animal gene knock out experiments fail. We have investigated a pathway through which HDAC1 affects cardiovascular and more specifically cardiomyocyte differentiation in ES cells by controlling expression of SOX17 and BMP2 during early differentiation. This data explains current discrepancies in the role of HDAC1 in cardiovascular differentiation and sheds light into a new pathway through which ES cells determine cardiovascular cell fate.
AB - Embryonic Stem Cells not only hold a lot of potential for use in regenerative medicine, but also provide an elegant and efficient way to study specific developmental processes and pathways in mammals when whole animal gene knock out experiments fail. We have investigated a pathway through which HDAC1 affects cardiovascular and more specifically cardiomyocyte differentiation in ES cells by controlling expression of SOX17 and BMP2 during early differentiation. This data explains current discrepancies in the role of HDAC1 in cardiovascular differentiation and sheds light into a new pathway through which ES cells determine cardiovascular cell fate.
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U2 - 10.1371/journal.pone.0045046
DO - 10.1371/journal.pone.0045046
M3 - Article
C2 - 22984607
AN - SCOPUS:84866342453
VL - 7
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 9
M1 - e45046
ER -