Elucidating new structural features of the triazole scaffold for the development of mPGES-1 inhibitors

Maria Giovanna Chini, Claudia Ferroni, Vincenza Cantone, Paolo Dambruoso, Greta Varchi, Antonella Pepe, Katrin Fischer, Carlo Pergola, Oliver Werz, Ines Bruno, Raffaele Riccio, Giuseppe Bifulco

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We report a new potent revisited version of a triazole-based inhibitor obtained by structure-based drug design on the human mPGES-1 crystal structure. Moreover, we disclosed the substitution with a halogen atom at position 5 as a new key factor influencing the biological activity on the mPGES-1 enzyme. This journal is

Original languageEnglish (US)
Pages (from-to)75-79
Number of pages5
JournalMedChemComm
Volume6
Issue number1
DOIs
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • Biochemistry
  • Pharmaceutical Science

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