Elevation of Plasma Concentrations of Arginine Vasopressin Following Perinatal Asphyxia

M. E. SPEER, W. A. GORMAN, Sheldon Kaplan, A. J. RUDOLPH

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Hypoxic ischemic encephalopathy is a major cause of mortality in neonates. Studies in experimental subjects have shown differing responses of plasma arginine vasopressin in hypoxia. Plasma arginine vasopressin levels, serum osmolality, urine osmolality and fluid intakes were measured in thirteen asphyxiated and nineteen control newborn infants during the first seventy-two hours of life. In the asphyxiated infants plasma arginine vasopressin was found to be elevated as compared to control infants on days one (p < 0.001) and two (p < 0.007) but not on day three of life. Urine osmolality was also elevated in the study patients on days one (p < 0.01) and two (p < 0.001) but not on day three, in spite of equal intakes of fluid on day one in both groups and significantly diminished fluid intake on days two and three in the study patients. Serum osmolality was not different between the two groups on any day studied, and was felt to be on the basis of diminished intake in the study infants. The data presented in this study support the concept that arginine vasopressin release occurs following perinatal asphyxia in term newborn infants.

Original languageEnglish (US)
Pages (from-to)610-614
Number of pages5
JournalActa Pædiatrica
Issue number5
StatePublished - Jan 1 1984


  • Asphyxia
  • arginine vasopressin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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