Elevated serum uric acid is associated with vascular inflammation but not coronary artery calcification in the healthy octogenarians: the Brazilian study on healthy aging

Rehan Malik, Ehimen C. Aneni, Sameer Shahrayar, Wladimir M. Freitas, Shozab S. Ali, Emir Veledar, Muhammad A. Latif, Muhammad Aziz, Rameez Ahmed, Sher A. Khan, Jeffrin Joseph, Hamid Feiz, Andrei Sposito, Khurram Nasir

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Background: There is a limited data on the association between serum uric acid (SUA) and cardiovascular disease (CVD) among the very elderly population. Aims: We evaluated the association of SUA, highly sensitive C-reactive protein (hs-CRP, a marker of vascular and systemic inflammation), and coronary artery calcification (CAC, a marker of subclinical CVD) in a cohort of Brazilian octogenarians (≥80 years) free from known clinical CVD. Methods: 208 individuals were included and evaluated for an association between increasing tertiles of SUA, elevated hs-CRP (>3 mg/dL), the presence and burden of CAC (CAC > 0 and CAC > 400). Results: The median hs-CRP was 1.9 (IQR = 1.0–3.4) mg/L and mean SUA was 5.3 (±1.4) mg/dL. The overall prevalence of elevated hs-CRP (>3 mg/dL) was 31 %. A significant increase in the prevalence of hs-CRP was noted across the higher SUA tertiles (p < 0.001) with 3.4 times the odds of having elevated hs-CRP in the highest SUA tertile (3.40; CI = 1.27–9.08). No association was noted with either the CAC presence and/or CAC burden (CAC > 0 or CAC > 400) across the increasing SUA tertiles. Discussion: In the healthy octogenarians, higher SUA levels are associated with vascular inflammation (hs-CRP) but not with coronary atherosclerosis (CAC); markers for the subclinical CVD.

Original languageEnglish (US)
Pages (from-to)359-362
Number of pages4
JournalAging Clinical and Experimental Research
Volume28
Issue number2
DOIs
StatePublished - Apr 1 2016

Keywords

  • CAC
  • hs-CRP and Serum Uric Acid
  • Octogenarians
  • Subclinical CVD

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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