Elevated red cell distribution width identifies elevated cardiovascular disease risk in patients with HIV infection

Sadeer G. Al-Kindi; Chang H. Kim; Stephen R. Morris; Michael L. Freeman; Nicholas T. Funderburg; Benigno Rodriguez; Grace A. McComsey; Jarrod E. Dalton; Daniel I. Simon; Michael M. Lederman; Chris T. Longenecker; David A. Zidar

doi:10.1097/QAI.0000000000001231

Elevated red cell distribution width identifies elevated cardiovascular disease risk in patients with HIV infection

Sadeer G. Al-Kindi, Chang H. Kim, Stephen R. Morris, Michael L. Freeman, Nicholas T. Funderburg, Benigno Rodriguez, Grace A. McComsey, Jarrod E. Dalton, Daniel I. Simon, Michael M. Lederman, Chris T. Longenecker, David A. Zidar

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Red cell distribution width (RDW) is linked to cardiovascular risk in the general population, an association that might be driven by inflammation. Whether this relationship holds for patients with HIV infection has not been previously studied. Using a large clinical registry, we show that elevated RDW (.14.5%) is independently associated with increased risk of coronary artery disease {odds ratio [OR] 1.39 [95% confidence interval (CI): 1.25 to 1.55]}, peripheral vascular disease [OR 1.41 (95% CI: 1.29 to 1.53)], myocardial infarction [1.43 (95% CI: 1.25 to 1.63)], heart failure [OR 2.23 (95% CI: 1.99 to 2.49)], and atrial fibrillation [OR 1.96 (95% CI: 1.64 to 2.33)]. In conclusion, in the context of the inflammatory milieu that accompanies HIV infection, RDW remains a powerful marker of cardiovascular disease.

Original language	English (US)
Pages (from-to)	298-302
Number of pages	5
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	74
Issue number	3
DOIs	https://doi.org/10.1097/QAI.0000000000001231
State	Published - Mar 1 2017

Keywords

Cardiovascular disease
Coronary
Heart failure
Peripheral
RDW

ASJC Scopus subject areas

Infectious Diseases
Pharmacology (medical)

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10.1097/QAI.0000000000001231

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Al-Kindi, S. G., Kim, C. H., Morris, S. R., Freeman, M. L., Funderburg, N. T., Rodriguez, B., McComsey, G. A., Dalton, J. E., Simon, D. I., Lederman, M. M., Longenecker, C. T., & Zidar, D. A. (2017). Elevated red cell distribution width identifies elevated cardiovascular disease risk in patients with HIV infection. Journal of Acquired Immune Deficiency Syndromes, 74(3), 298-302. https://doi.org/10.1097/QAI.0000000000001231

Al-Kindi, SG, Kim, CH, Morris, SR, Freeman, ML, Funderburg, NT, Rodriguez, B, McComsey, GA, Dalton, JE, Simon, DI, Lederman, MM, Longenecker, CT & Zidar, DA 2017, 'Elevated red cell distribution width identifies elevated cardiovascular disease risk in patients with HIV infection', Journal of Acquired Immune Deficiency Syndromes, vol. 74, no. 3, pp. 298-302. https://doi.org/10.1097/QAI.0000000000001231

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abstract = "Red cell distribution width (RDW) is linked to cardiovascular risk in the general population, an association that might be driven by inflammation. Whether this relationship holds for patients with HIV infection has not been previously studied. Using a large clinical registry, we show that elevated RDW (.14.5%) is independently associated with increased risk of coronary artery disease {odds ratio [OR] 1.39 [95% confidence interval (CI): 1.25 to 1.55]}, peripheral vascular disease [OR 1.41 (95% CI: 1.29 to 1.53)], myocardial infarction [1.43 (95% CI: 1.25 to 1.63)], heart failure [OR 2.23 (95% CI: 1.99 to 2.49)], and atrial fibrillation [OR 1.96 (95% CI: 1.64 to 2.33)]. In conclusion, in the context of the inflammatory milieu that accompanies HIV infection, RDW remains a powerful marker of cardiovascular disease.",

keywords = "Cardiovascular disease, Coronary, Heart failure, Peripheral, RDW",

author = "Al-Kindi, {Sadeer G.} and Kim, {Chang H.} and Morris, {Stephen R.} and Freeman, {Michael L.} and Funderburg, {Nicholas T.} and Benigno Rodriguez and McComsey, {Grace A.} and Dalton, {Jarrod E.} and Simon, {Daniel I.} and Lederman, {Michael M.} and Longenecker, {Chris T.} and Zidar, {David A.}",

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AU - Funderburg, Nicholas T.

AU - Rodriguez, Benigno

AU - McComsey, Grace A.

AU - Dalton, Jarrod E.

AU - Simon, Daniel I.

AU - Lederman, Michael M.

AU - Longenecker, Chris T.

AU - Zidar, David A.

PY - 2017/3/1

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N2 - Red cell distribution width (RDW) is linked to cardiovascular risk in the general population, an association that might be driven by inflammation. Whether this relationship holds for patients with HIV infection has not been previously studied. Using a large clinical registry, we show that elevated RDW (.14.5%) is independently associated with increased risk of coronary artery disease {odds ratio [OR] 1.39 [95% confidence interval (CI): 1.25 to 1.55]}, peripheral vascular disease [OR 1.41 (95% CI: 1.29 to 1.53)], myocardial infarction [1.43 (95% CI: 1.25 to 1.63)], heart failure [OR 2.23 (95% CI: 1.99 to 2.49)], and atrial fibrillation [OR 1.96 (95% CI: 1.64 to 2.33)]. In conclusion, in the context of the inflammatory milieu that accompanies HIV infection, RDW remains a powerful marker of cardiovascular disease.

AB - Red cell distribution width (RDW) is linked to cardiovascular risk in the general population, an association that might be driven by inflammation. Whether this relationship holds for patients with HIV infection has not been previously studied. Using a large clinical registry, we show that elevated RDW (.14.5%) is independently associated with increased risk of coronary artery disease {odds ratio [OR] 1.39 [95% confidence interval (CI): 1.25 to 1.55]}, peripheral vascular disease [OR 1.41 (95% CI: 1.29 to 1.53)], myocardial infarction [1.43 (95% CI: 1.25 to 1.63)], heart failure [OR 2.23 (95% CI: 1.99 to 2.49)], and atrial fibrillation [OR 1.96 (95% CI: 1.64 to 2.33)]. In conclusion, in the context of the inflammatory milieu that accompanies HIV infection, RDW remains a powerful marker of cardiovascular disease.

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Elevated red cell distribution width identifies elevated cardiovascular disease risk in patients with HIV infection

Abstract

Keywords

ASJC Scopus subject areas

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