Element distribution in the brain of rats exposed to lanthanum measured by synchrotron radiation X-ray fluorescence

L. X. Feng, H. Q. Xiao, X. He, Z. J. Li, F. L. Li, N. Q. Liu, Z. F. Chai, Y. L. Zhao, Y. Y. Huang, W. He, Z. Y. Zhang

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

To investigate the effects of lanthanum exposure on regional distribution of inorganic elements in rat brain. Wistar rats were exposed to lanthanum chloride through oral administration at 0, 0.1, 2, and 40 mg/kg concentration for 6 months. The elements such as Cl, K, Ca, Fe, Cu, and Zn were identified in the brain slices by synchrotron radiation X-ray fluorescence (SRXRF) analysis. Differences of brain elemental distributions were noticed. Cl, Ca, and Zn were primarily concentrated in hippocampus of the controls. With the increase of the lanthanum dosage, the Ca and Zn levels significantly decreased, while the Cu levels significantly elevated in cortex, hippocampus and thalamus. Our results suggest that subchronic lanthanum exposure in rats appears to change elemental distributions in brain.

Original languageEnglish (US)
Pages (from-to)333-337
Number of pages5
JournalJournal of Radioanalytical and Nuclear Chemistry
Volume272
Issue number2
DOIs
StatePublished - May 1 2007

ASJC Scopus subject areas

  • Analytical Chemistry
  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging
  • Pollution
  • Spectroscopy
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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