Electrostatically gated nanofluidic membrane for ultra-low power controlled drug delivery

Research output: Contribution to journalArticle

Nicola Di Trani, Antonia Silvestri, Antons Sizovs, Yu Wang, Donald R. Erm, Danilo Demarchi, Xuewu Liu, Alessandro Grattoni

Patient-centered therapeutic management for chronic medical conditions is a desired but unmet need, largely attributable to the lack of adequate technologies for tailored drug administration. While triggered devices that control the delivery of therapeutics exist, they often rely on impractical continuous external activation. As such, next generation continuously tunable drug delivery systems independent of sustained external activation remain an elusive goal. Here we present the development and demonstration of a silicon carbide (SiC)-coated nanofluidic membrane that achieves reproducible and tunable control of drug releaseviaelectrostatic gating. By applying a low-intensity voltage to a buried electrode, we showed repeatable and reproduciblein vitrorelease modulation of three model analytes. A small fluorophore (Alexa Fluor 647), a large polymer poly(sodium 4-styrenesulfonate) and a medically relevant agent (DNA), were selected as representatives of small molecule therapeutics, polymeric drug carriers, and biological therapeutics, respectively. Unlike other drug delivery systems, our technology performed consistently over numerous cycles of voltage modulation, for over 11 days. Importantly, low power consumption and minimal leakage currents were achieved during the study. Further, the SiC coating maintained integrity and chemical inertness, shielding the membrane from degradation under simulated physiological and accelerated conditions for over 4 months. Through leveraging the flexibility offered by electrostatic gating control, our technology provides a valuable strategy for tunable delivery, setting the foundation for the next generation of drug delivery systems.

Original languageEnglish (US)
Pages (from-to)1562-1576
Number of pages15
JournalLab on a Chip
Volume20
Issue number9
DOIs
StatePublished - May 7 2020

PMID: 32249279

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Electrostatically gated nanofluidic membrane for ultra-low power controlled drug delivery. / Di Trani, Nicola; Silvestri, Antonia; Sizovs, Antons; Wang, Yu; Erm, Donald R.; Demarchi, Danilo; Liu, Xuewu; Grattoni, Alessandro.

In: Lab on a Chip, Vol. 20, No. 9, 07.05.2020, p. 1562-1576.

Research output: Contribution to journalArticle

Harvard

Di Trani, N, Silvestri, A, Sizovs, A, Wang, Y, Erm, DR, Demarchi, D, Liu, X & Grattoni, A 2020, 'Electrostatically gated nanofluidic membrane for ultra-low power controlled drug delivery' Lab on a Chip, vol. 20, no. 9, pp. 1562-1576. https://doi.org/10.1039/d0lc00121j

APA

Di Trani, N., Silvestri, A., Sizovs, A., Wang, Y., Erm, D. R., Demarchi, D., ... Grattoni, A. (2020). Electrostatically gated nanofluidic membrane for ultra-low power controlled drug delivery. Lab on a Chip, 20(9), 1562-1576. https://doi.org/10.1039/d0lc00121j

Vancouver

Di Trani N, Silvestri A, Sizovs A, Wang Y, Erm DR, Demarchi D et al. Electrostatically gated nanofluidic membrane for ultra-low power controlled drug delivery. Lab on a Chip. 2020 May 7;20(9):1562-1576. https://doi.org/10.1039/d0lc00121j

Author

Di Trani, Nicola ; Silvestri, Antonia ; Sizovs, Antons ; Wang, Yu ; Erm, Donald R. ; Demarchi, Danilo ; Liu, Xuewu ; Grattoni, Alessandro. / Electrostatically gated nanofluidic membrane for ultra-low power controlled drug delivery. In: Lab on a Chip. 2020 ; Vol. 20, No. 9. pp. 1562-1576.

BibTeX

@article{c6fedcb7909347839b3eb834d2780650,
title = "Electrostatically gated nanofluidic membrane for ultra-low power controlled drug delivery",
abstract = "Patient-centered therapeutic management for chronic medical conditions is a desired but unmet need, largely attributable to the lack of adequate technologies for tailored drug administration. While triggered devices that control the delivery of therapeutics exist, they often rely on impractical continuous external activation. As such, next generation continuously tunable drug delivery systems independent of sustained external activation remain an elusive goal. Here we present the development and demonstration of a silicon carbide (SiC)-coated nanofluidic membrane that achieves reproducible and tunable control of drug releaseviaelectrostatic gating. By applying a low-intensity voltage to a buried electrode, we showed repeatable and reproduciblein vitrorelease modulation of three model analytes. A small fluorophore (Alexa Fluor 647), a large polymer poly(sodium 4-styrenesulfonate) and a medically relevant agent (DNA), were selected as representatives of small molecule therapeutics, polymeric drug carriers, and biological therapeutics, respectively. Unlike other drug delivery systems, our technology performed consistently over numerous cycles of voltage modulation, for over 11 days. Importantly, low power consumption and minimal leakage currents were achieved during the study. Further, the SiC coating maintained integrity and chemical inertness, shielding the membrane from degradation under simulated physiological and accelerated conditions for over 4 months. Through leveraging the flexibility offered by electrostatic gating control, our technology provides a valuable strategy for tunable delivery, setting the foundation for the next generation of drug delivery systems.",
author = "{Di Trani}, Nicola and Antonia Silvestri and Antons Sizovs and Yu Wang and Erm, {Donald R.} and Danilo Demarchi and Xuewu Liu and Alessandro Grattoni",
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RIS

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T1 - Electrostatically gated nanofluidic membrane for ultra-low power controlled drug delivery

AU - Di Trani, Nicola

AU - Silvestri, Antonia

AU - Sizovs, Antons

AU - Wang, Yu

AU - Erm, Donald R.

AU - Demarchi, Danilo

AU - Liu, Xuewu

AU - Grattoni, Alessandro

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AB - Patient-centered therapeutic management for chronic medical conditions is a desired but unmet need, largely attributable to the lack of adequate technologies for tailored drug administration. While triggered devices that control the delivery of therapeutics exist, they often rely on impractical continuous external activation. As such, next generation continuously tunable drug delivery systems independent of sustained external activation remain an elusive goal. Here we present the development and demonstration of a silicon carbide (SiC)-coated nanofluidic membrane that achieves reproducible and tunable control of drug releaseviaelectrostatic gating. By applying a low-intensity voltage to a buried electrode, we showed repeatable and reproduciblein vitrorelease modulation of three model analytes. A small fluorophore (Alexa Fluor 647), a large polymer poly(sodium 4-styrenesulfonate) and a medically relevant agent (DNA), were selected as representatives of small molecule therapeutics, polymeric drug carriers, and biological therapeutics, respectively. Unlike other drug delivery systems, our technology performed consistently over numerous cycles of voltage modulation, for over 11 days. Importantly, low power consumption and minimal leakage currents were achieved during the study. Further, the SiC coating maintained integrity and chemical inertness, shielding the membrane from degradation under simulated physiological and accelerated conditions for over 4 months. Through leveraging the flexibility offered by electrostatic gating control, our technology provides a valuable strategy for tunable delivery, setting the foundation for the next generation of drug delivery systems.

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