TY - JOUR
T1 - Electrostatically gated nanofluidic membrane for ultra-low power controlled drug delivery
AU - Di Trani, Nicola
AU - Silvestri, Antonia
AU - Sizovs, Antons
AU - Wang, Yu
AU - Erm, Donald R.
AU - Demarchi, Danilo
AU - Liu, Xuewu
AU - Grattoni, Alessandro
N1 - Funding Information:
We thank Valentina Serafini for her support in experimental studies and Dr. Jianhua (James) Gu from the electron microscopy core of the Houston Methodist Research Institute. Funding support was provided by the Houston Methodist Research Institute and NIH-NIGMS R01GM127558. Additional support was received through the Frank J. and Jean Raymond Centennial Chair Endowment.
Publisher Copyright:
© The Royal Society of Chemistry 2020.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/5/7
Y1 - 2020/5/7
N2 - Patient-centered therapeutic management for chronic medical conditions is a desired but unmet need, largely attributable to the lack of adequate technologies for tailored drug administration. While triggered devices that control the delivery of therapeutics exist, they often rely on impractical continuous external activation. As such, next generation continuously tunable drug delivery systems independent of sustained external activation remain an elusive goal. Here we present the development and demonstration of a silicon carbide (SiC)-coated nanofluidic membrane that achieves reproducible and tunable control of drug releaseviaelectrostatic gating. By applying a low-intensity voltage to a buried electrode, we showed repeatable and reproduciblein vitrorelease modulation of three model analytes. A small fluorophore (Alexa Fluor 647), a large polymer poly(sodium 4-styrenesulfonate) and a medically relevant agent (DNA), were selected as representatives of small molecule therapeutics, polymeric drug carriers, and biological therapeutics, respectively. Unlike other drug delivery systems, our technology performed consistently over numerous cycles of voltage modulation, for over 11 days. Importantly, low power consumption and minimal leakage currents were achieved during the study. Further, the SiC coating maintained integrity and chemical inertness, shielding the membrane from degradation under simulated physiological and accelerated conditions for over 4 months. Through leveraging the flexibility offered by electrostatic gating control, our technology provides a valuable strategy for tunable delivery, setting the foundation for the next generation of drug delivery systems.
AB - Patient-centered therapeutic management for chronic medical conditions is a desired but unmet need, largely attributable to the lack of adequate technologies for tailored drug administration. While triggered devices that control the delivery of therapeutics exist, they often rely on impractical continuous external activation. As such, next generation continuously tunable drug delivery systems independent of sustained external activation remain an elusive goal. Here we present the development and demonstration of a silicon carbide (SiC)-coated nanofluidic membrane that achieves reproducible and tunable control of drug releaseviaelectrostatic gating. By applying a low-intensity voltage to a buried electrode, we showed repeatable and reproduciblein vitrorelease modulation of three model analytes. A small fluorophore (Alexa Fluor 647), a large polymer poly(sodium 4-styrenesulfonate) and a medically relevant agent (DNA), were selected as representatives of small molecule therapeutics, polymeric drug carriers, and biological therapeutics, respectively. Unlike other drug delivery systems, our technology performed consistently over numerous cycles of voltage modulation, for over 11 days. Importantly, low power consumption and minimal leakage currents were achieved during the study. Further, the SiC coating maintained integrity and chemical inertness, shielding the membrane from degradation under simulated physiological and accelerated conditions for over 4 months. Through leveraging the flexibility offered by electrostatic gating control, our technology provides a valuable strategy for tunable delivery, setting the foundation for the next generation of drug delivery systems.
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U2 - 10.1039/d0lc00121j
DO - 10.1039/d0lc00121j
M3 - Article
C2 - 32249279
AN - SCOPUS:85084272021
VL - 20
SP - 1562
EP - 1576
JO - Lab on a Chip - Miniaturisation for Chemistry and Biology
JF - Lab on a Chip - Miniaturisation for Chemistry and Biology
SN - 1473-0197
IS - 9
ER -