Electron microscopy in the diagnosis of small round cell tumors of bone

Janine K. Mawad, Bruce Mackay, A. Kevin Raymond, Alberto Ayala

Research output: Contribution to journalArticle

10 Scopus citations


Small round cell tumors involving bone can present problems in differential diagnosis by light microscopy. In exploring the role of electron microscopy in this situation, seven small cell osteosarcomas and seven mesenchymal chondrosarcomas were examined by electron microscopy and compared with typical and atypical Ewing's sarcomas. There is much overlap in the ultrastructural features of these tumors, but electron microscopy is helpful to establish or confirm a diagnosis of typical Ewing's sarcoma and, if representative matrix is present, of small cell osteosarcoma.

Original languageEnglish (US)
Pages (from-to)263-268
Number of pages6
JournalUltrastructural Pathology
Issue number1-2
StatePublished - Jan 1 1994


  • bone tumors
  • chondrosarcoma
  • Ewing's tumor
  • osteosarcoma
  • small round cell tumors

ASJC Scopus subject areas

  • Structural Biology
  • Pathology and Forensic Medicine
  • Instrumentation

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