Electroconductive Gels for Controlled Electrorelease of Bioactive Peptides

Anthony Guiseppi-Elie, Ann M. Wilson, Andrew S. Sujdak

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

We have synthesized highly hydrophilic, chemically responsive materials we call electroconductive gels. They are formed as an interpenetrating network of an electroconductive polymer and a hydrophilic hydrogel. Polymers were formulated form UV polymerizable hydrophilic monomer such as hydroxyethyl methacrylate (HEMA), N-[tris(hydroxymethyl)methyl] acrylamide (HMMA), and tetraethylene glycol diacrylate (TEGDA), and oxidatively polymerizable electroactive monomer such as aniline and dianiline. The hydrogel network was formed by UV-photoinitiated polymerization and the electroconductive polymer subsequently formed by chemical oxidative coupling induced by immersion in aqueous FeCl3 solutions, by electropolymerization, or by a combination of these methods. Interaction between both networks was accorded by the difunctional 3-sulfopropylmethacrylate (SPM). These materials retain more electroactivity and display fast cation transport with K+ diffusivity (Do=5.31×10-7 cm2 s-1) that are an order of magnitude larger than that of electropolymerized polyaniline (Do=3.12×10-8 cm2 s-1). The electroconductive polyaniline gels are shown to be more stable under ambient conditions and to efficiently imbibe and release Ca++ under electrostimulation.

Original languageEnglish (US)
Pages (from-to)185-202
Number of pages18
JournalACS Symposium Series
Volume709
DOIs
StatePublished - 1998

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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