Electroconductive Gels for Controlled Electrorelease of Bioactive Peptides

Anthony Guiseppi-Elie, Ann M. Wilson, Andrew S. Sujdak

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

We have synthesized highly hydrophilic, chemically responsive materials we call electroconductive gels. They are formed as an interpenetrating network of an electroconductive polymer and a hydrophilic hydrogel. Polymers were formulated form UV polymerizable hydrophilic monomer such as hydroxyethyl methacrylate (HEMA), N-[tris(hydroxymethyl)methyl] acrylamide (HMMA), and tetraethylene glycol diacrylate (TEGDA), and oxidatively polymerizable electroactive monomer such as aniline and dianiline. The hydrogel network was formed by UV-photoinitiated polymerization and the electroconductive polymer subsequently formed by chemical oxidative coupling induced by immersion in aqueous FeCl3 solutions, by electropolymerization, or by a combination of these methods. Interaction between both networks was accorded by the difunctional 3-sulfopropylmethacrylate (SPM). These materials retain more electroactivity and display fast cation transport with K+ diffusivity (Do=5.31×10-7 cm2 s-1) that are an order of magnitude larger than that of electropolymerized polyaniline (Do=3.12×10-8 cm2 s-1). The electroconductive polyaniline gels are shown to be more stable under ambient conditions and to efficiently imbibe and release Ca++ under electrostimulation.

Original languageEnglish (US)
Pages (from-to)185-202
Number of pages18
JournalACS Symposium Series
Volume709
DOIs
StatePublished - 1998

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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