Electrical stimulation of cerebellar fastigial nucleus fails to rematch blood flow and metabolism in focal ischemic infarctions

Eugene V. Golanov, Seiji Yamamoto, Donald J. Reis

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Electrical stimulation of the cerebellar fastigial nucleus (FN) in rat (1 h) reduces, by 50%, the infarction produced by occlusion of the middle cerebral artery (MCAO). We investigated whether salvage was associated with elevations in regional cerebral blood flow (rCBF) and/or reductions of regional cerebral glucose utilization (rCGU) in the retrievable zone (RZ). rCGU and rCBF were measured autoradiographically 1 h after MCAO. MCAO reduced rCBF to <15% in the irretrievable zone (IZ) and ~50% in the RZ (P < 0.01 for each) while FN stimulation alone globally elevated rCBF by ~60% (P < 0.01). rCGU was not changed. After MCAO, FN stimulation failed to increase the reduced rCBF but elevated rCGU globally (to ~30%). Reductions of focal ischemic infarctions by stimulating FN cannot be attributed to changes in rCBF and or rCGU.

Original languageEnglish (US)
Pages (from-to)181-184
Number of pages4
JournalNeuroscience Letters
Volume210
Issue number3
DOIs
StatePublished - Jun 7 1996

Keywords

  • Autoradiography
  • Electrical stimulation
  • Fastigial nucleus
  • Local ischemia
  • Middle cerebral artery
  • Regional cerebral blood flow
  • Regional cerebral glucose utilization

ASJC Scopus subject areas

  • Neuroscience(all)

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