Elastographic characterization of HIFU-induced lesions in canine livers

Raffaella Righetti, Faouzi Kallel, R. Jason Stafford, Roger E. Price, Thomas A. Krouskop, John D. Hazle, Jonathan Ophir

Research output: Contribution to journalArticlepeer-review

177 Scopus citations


The elastographic visualization and evaluation of high-intensity focused ultrasound (HIFU)-induced lesions were investigated. The lesions were induced in vitro in freshly excised canine livers. The use of different treatment intensity levels and exposure times resulted in lesions of different sizes. Each lesion was clearly depicted by the corresponding elastogram as being an area harder than the background. The strain contrast of the lesion/background was found to be dependent on the level of energy deposition. A lesion/background strain contrast between -2.5 dB and -3.5 dB was found to completely define the entire zone of tissue damage. The area of tissue damage was automatically estimated from the elastograms by evaluating the number of pixels enclosed inside the isointensity contour lines corresponding to a strain contrast of -2.5, -3 and -3.5 dB. The area of the lesion was measured from a tissue photograph obtained at approximately the same plane where elastographic data were collected. The estimated lesion areas ranged between approximately 10 mm2 and 110 mm2. A high correlation between the damaged areas as depicted by the elastograms and the corresponding areas as measured from the gross pathology photographs was found (r2 = 0.93, p value < 0.0004, n = 16). This statistically significant high correlation demonstrates that elastography has the potential to become a reliable and accurate modality for HIFU therapy monitoring. Copyright (C) 1999 World Federation for Ultrasound in Medicine and Biology.

Original languageEnglish (US)
Pages (from-to)1099-1113
Number of pages15
JournalUltrasound in Medicine and Biology
Issue number7
StatePublished - Sep 1999


  • Elastography
  • HIFU
  • Minimally invasive surgery
  • Strain
  • Tissue ablation
  • Ultrasound

ASJC Scopus subject areas

  • Biophysics
  • Radiological and Ultrasound Technology
  • Acoustics and Ultrasonics


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