Elastographic characterization of HIFU-induced lesions

Raffaella Righetti, F. Kallel, R. J. Stafford, R. E. Price, T. Krouskop, J. D. Hazle, J. Ophir

Research output: Contribution to journalConference articlepeer-review


The elastographic characterization of high intensity focused ultrasound (HIFU) induced lesions was investigated. The lesions were induced in vitro in 16 excised canine livers, using different treatment intensity levels and exposure times. In each case, the lesion was clearly depicted by the corresponding elastogram, as a hard area embedded in a softer background. The strain contrast of the lesion/background was found to depend on the temperature increase inside the exposed tissue during the treatment. The area of the lesion as it appeared in the elastogram was automatically computed and correlated with the corresponding area in the gross pathology photograph. The estimated areas ranged between approximately 10 mm2 and 110 mm2. A high correlation between the areas of damage as depicted by the elastogram, and the corresponding areas as measured from the gross pathology photograph was found (r2 = 0.93, p-value<0.0004, n = 16). This statistically significant high correlation demonstrates that elastography has the potential to become a reliable and accurate modality for HIFU therapy monitoring.

Original languageEnglish (US)
JournalUltrasound in Medicine and Biology
Issue numberSUPPL. 2
StatePublished - Jan 1 2000
EventThe 9th Congress of World Federation for Ultrasound in Medicine and Biology - Florence, Italy
Duration: May 6 2000May 10 2000

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics


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