TY - JOUR
T1 - Efficient Near Infrared Light Triggered Nitric Oxide Release Nanocomposites for Sensitizing Mild Photothermal Therapy
AU - Zhang, Xiao
AU - Du, Jiangfeng
AU - Guo, Zhao
AU - Yu, Jie
AU - Gao, Qin
AU - Yin, Wenyan
AU - Zhu, Shuang
AU - Gu, Zhanjun
AU - Zhao, Yuliang
N1 - Funding Information:
This work was supported by the National Basic Research Program of China (2016YFA2021600 and 2016YFA0202104), the National Natural Science Foundation of China (51772292, 31571015, 11621505, 11435002, and 21320102003), and the Chinese Academy of Sciences Youth Innovation Promotion Association (2013007). All animal experiment procedures used were compliant with the Chinese Association for Laboratory Animal Sciences.
Publisher Copyright:
© 2018 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2019/2/6
Y1 - 2019/2/6
N2 - Mild photothermal therapy (PTT), as a new anticancer therapeutic strategy, faces big challenges of limited therapeutic accuracy and side-effects due to uneven heat distribution. Here, near infrared triggered nitric oxide (NO) release nanocomposites based on bismuth sulfide (Bi2S3) nanoparticles and bis-N-nitroso compounds (BNN) are constructed for NO-enhanced mild photothermal therapy. Upon 808 nm irradiation, the high photothermal conversion efficiency and on-demand NO release are realized simultaneously. Due to the unique properties of NO, enhanced antitumor efficacy of mild PTT based on BNN-Bi2S3 nanocomposites is achieved in vitro and in vivo. Mechanism studies reveal that the exogenous NO from BNN-Bi2S3 could not only impair the autophagic self-repairing ability of tumor cells in situ, but also diffuse to the surrounding cells to enhance the therapeutic effect. This work points out a strategy to overcome the difficulties in mild PTT, and has potentials for further exploitation of NO-sensitized synergistic cancer therapy.
AB - Mild photothermal therapy (PTT), as a new anticancer therapeutic strategy, faces big challenges of limited therapeutic accuracy and side-effects due to uneven heat distribution. Here, near infrared triggered nitric oxide (NO) release nanocomposites based on bismuth sulfide (Bi2S3) nanoparticles and bis-N-nitroso compounds (BNN) are constructed for NO-enhanced mild photothermal therapy. Upon 808 nm irradiation, the high photothermal conversion efficiency and on-demand NO release are realized simultaneously. Due to the unique properties of NO, enhanced antitumor efficacy of mild PTT based on BNN-Bi2S3 nanocomposites is achieved in vitro and in vivo. Mechanism studies reveal that the exogenous NO from BNN-Bi2S3 could not only impair the autophagic self-repairing ability of tumor cells in situ, but also diffuse to the surrounding cells to enhance the therapeutic effect. This work points out a strategy to overcome the difficulties in mild PTT, and has potentials for further exploitation of NO-sensitized synergistic cancer therapy.
KW - NIR triggered
KW - NO-sensitized synergistic therapy
KW - autophagy
KW - mild photothermal therapy
KW - nitric oxide release
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U2 - 10.1002/advs.201801122
DO - 10.1002/advs.201801122
M3 - Article
AN - SCOPUS:85058229044
VL - 6
JO - Advanced Science
JF - Advanced Science
SN - 2198-3844
IS - 3
M1 - 1801122
ER -