@article{e42ff0e5229f47fc91cfd7b7b6ff231b,
title = "Efficient assessment of developmental, surgical and pathological lymphangiogenesis using a lymphatic reporter mouse and its embryonic stem cells",
abstract = "Several lymphatic reporter mouse lines have recently been developed to significantly improve imaging of lymphatic vessels. Nonetheless, the usage of direct visualization of lymphatic vessels has not been fully explored and documented. Here, we characterized a new Prox1-tdTomato transgenic lymphatic reporter mouse line, and demonstrated how this animal tool enables the researchers to efficiently assess developmental, surgical and pathological lymphangiogenesis by direct visualization of lymphatic vessels. Moreover, we have derived embryonic stem cells from this reporter line, and successfully differentiated them into lymphatic vessels in vivo. In conclusion, these experimental tools and techniques will help advance lymphatic research.",
author = "Mingu Hong and Eunson Jung and Sara Yang and Wonhyuek Jung and Seong, {Young Jin} and Eunkyung Park and Athanasios Bramos and Kim, {Kyu Eui} and Sunju Lee and George Daghlian and Seo, {Jung In} and Inho Choi and Choi, {In Seon} and Koh, {Chester J.} and Agnieszka Kobielak and Ying, {Qi Long} and Maxwell Johnson and Daniel Gardner and Wong, {Alex K.} and Dongwon Choi and Hong, {Young Kwon}",
note = "Funding Information: This study was supported by American Heart Association (13GRNT17060131 to YKH), National Institute of Health (R01HL121036 & R21HL119583 to YKH) and Southern California Clinical and Translational Science Institute (SC-CTSI, KL2TR000131 to AKW). Publisher Copyright: {\textcopyright} 2016 Hong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",
year = "2016",
month = jun,
day = "1",
doi = "10.1371/journal.pone.0157126",
language = "English (US)",
volume = "11",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "6",
}