Efficacy of tedizolid against enterococci and staphylococci, including CFR strains, in a mouse peritonitis model

Kavindra V. Singh; Cesar A. Arias; Barbara E. Murray

doi:10.1128/AAC.02627-18

Efficacy of tedizolid against enterococci and staphylococci, including CFR strains, in a mouse peritonitis model

Kavindra V. Singh, Cesar A. Arias, Barbara E. Murray

Houston Methodist

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

In a mouse peritonitis model, tedizolid was comparable to linezolid and daptomycin against an Enterococcus faecium strain (VAN^r, AMP^r), an Enterococcus faecalis strain, and a methicillin-resistant Staphylococcus aureus (MRSA) strain with and without cfr. Against a cfr(B) E. faecium, tedizolid was inferior in vivo to linezolid and daptomycin, despite an 4-fold lower MIC.

Original language	English (US)
Article number	e02627-18
Journal	Antimicrobial Agents and Chemotherapy
Volume	63
Issue number	4
DOIs	https://doi.org/10.1128/AAC.02627-18
State	Published - Apr 2019

Keywords

Mouse peritonitis
Tedizolid

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

Divisions

Infectious Disease

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10.1128/AAC.02627-18

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abstract = "In a mouse peritonitis model, tedizolid was comparable to linezolid and daptomycin against an Enterococcus faecium strain (VANr, AMPr), an Enterococcus faecalis strain, and a methicillin-resistant Staphylococcus aureus (MRSA) strain with and without cfr. Against a cfr(B) E. faecium, tedizolid was inferior in vivo to linezolid and daptomycin, despite an 4-fold lower MIC.",

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AB - In a mouse peritonitis model, tedizolid was comparable to linezolid and daptomycin against an Enterococcus faecium strain (VANr, AMPr), an Enterococcus faecalis strain, and a methicillin-resistant Staphylococcus aureus (MRSA) strain with and without cfr. Against a cfr(B) E. faecium, tedizolid was inferior in vivo to linezolid and daptomycin, despite an 4-fold lower MIC.

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Efficacy of tedizolid against enterococci and staphylococci, including CFR strains, in a mouse peritonitis model

Abstract

Keywords

ASJC Scopus subject areas

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