Efficacy of polyphenon E, red ginseng, and rapamycin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice

Ying Yan, Yian Wang, Qing Tan, Yukihiko Hara, Taik Koo Yun, Ronald A. Lubet, Ming You

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

The objective of this investigation was to determine the efficacy of several novel agents in preventing lung tumorigenesis in mice. We evaluated polyphenon E, red ginseng, and rapamycin in A/J mice treated with the tobacco-specific carcinogen benzo(a)pyrene for their ability to inhibit pulmonary adenoma formation and growth. We found that treatment with polyphenon E exhibited a significant reduction on both tumor multiplicity and tumor load (tumor multiplicity x tumor volvolume) in a dose-dependent fashion. Polyphenon E (2% wt/wt) in the diet reduced tumor multiplicity by 46% and tumor load by 94%. This result provided key evidence in support of a phase II clinical chemoprevention trial of lung cancer. Administration of red ginseng in drinking water decreased tumor multiplicity by 36% and tumor load by 70%. The mammalian target of rapamycin inhibitor rapamycin showed significant efficacy against lung tumor growth in the tumor progression protocol and reduced tumor load by 84%. The results of these investigations demonstrate that polyphenon E, red ginseng, and rapamycin significantly inhibit pulmonary adenoma formation and growth in A/J mice.

Original languageEnglish (US)
Pages (from-to)52-58
Number of pages7
JournalNeoplasia
Volume8
Issue number1
DOIs
StatePublished - Jan 2006

Keywords

  • Chemoprevention
  • Lung tumor
  • Polyphenon E
  • Rapamycin
  • Red ginseng

ASJC Scopus subject areas

  • Cancer Research

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