Efficacy of omadacycline against multidrug-resistant enterococcus faecium Strains in a Mouse Peritonitis Model

Kavindra V. Singh; Cesar A. Arias; Barbara E. Murray

doi:10.1128/AAC.00709-21

Efficacy of omadacycline against multidrug-resistant enterococcus faecium Strains in a Mouse Peritonitis Model

Kavindra V. Singh, Cesar A. Arias, Barbara E. Murray

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Omadacycline (OMC) showed better in vitro potency than daptomycin (DAP) or vancomycin (VAN) against Van r, Amp r, DAP-nonsusceptible, linezolid-resistant, cfr(B) + Enterococcus faecium strains. In a mouse peritonitis model, OMC also showed significantly better animal survival during the study and at its end than DAP or VAN with these E. faecium strains. However, OMC, DAP, and VAN showed comparable in vitro and in vivo efficacies against a non-vancomycin-resistant, tetracycline-resistant, DAP-susceptible E. faecium strain.

Original language	English (US)
Article number	00709
Pages (from-to)	e0070921
Journal	Antimicrobial Agents and Chemotherapy
Volume	65
Issue number	9
DOIs	https://doi.org/10.1128/AAC.00709-21
State	Published - Aug 17 2021

Keywords

E. faecium
Mouse peritonitis
Omadacycline
Microbial Sensitivity Tests
Enterococcus faecium
Animals
Tetracyclines/pharmacology
Peritonitis/drug therapy
Mice
Gram-Positive Bacterial Infections/drug therapy
Anti-Bacterial Agents/pharmacology

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology

Divisions

Infectious Disease

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10.1128/AAC.00709-21

Cite this

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title = "Efficacy of omadacycline against multidrug-resistant enterococcus faecium Strains in a Mouse Peritonitis Model",

abstract = "Omadacycline (OMC) showed better in vitro potency than daptomycin (DAP) or vancomycin (VAN) against Van r, Amp r, DAP-nonsusceptible, linezolid-resistant, cfr(B) + Enterococcus faecium strains. In a mouse peritonitis model, OMC also showed significantly better animal survival during the study and at its end than DAP or VAN with these E. faecium strains. However, OMC, DAP, and VAN showed comparable in vitro and in vivo efficacies against a non-vancomycin-resistant, tetracycline-resistant, DAP-susceptible E. faecium strain. ",

keywords = "E. faecium, Mouse peritonitis, Omadacycline, Microbial Sensitivity Tests, Enterococcus faecium, Animals, Tetracyclines/pharmacology, Peritonitis/drug therapy, Mice, Gram-Positive Bacterial Infections/drug therapy, Anti-Bacterial Agents/pharmacology",

author = "Singh, \{Kavindra V.\} and Arias, \{Cesar A.\} and Murray, \{Barbara E.\}",

note = "Funding Information: This work was supported by Paratek Pharmaceuticals, Inc., in the form of an investigator-initiated grant to the University of Texas Health Science Center, McGovern Medical School (B.E.M., PI). C.A.A. was partially supported by NIH/NIAID grants R01 AI134637, R21 AI143229, K24 AI121296, P01-AI152999-01, R01-AI148342-01, T32AI141349, and UM1AI104681, a UTHealth Presidential Award, and a University of Texas System STARS Award. B.E.M. and K.V.S. were supported in part by R21 AI133289-01A1, R21 AI143229, and R01 AI121400 from NIAID. We thank Karen Jacques-Palaz for technical assistance. Publisher Copyright: Copyright {\textcopyright} 2021 American Society for Microbiology. All Rights Reserved.",

year = "2021",

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language = "English (US)",

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AU - Singh, Kavindra V.

AU - Arias, Cesar A.

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N1 - Funding Information: This work was supported by Paratek Pharmaceuticals, Inc., in the form of an investigator-initiated grant to the University of Texas Health Science Center, McGovern Medical School (B.E.M., PI). C.A.A. was partially supported by NIH/NIAID grants R01 AI134637, R21 AI143229, K24 AI121296, P01-AI152999-01, R01-AI148342-01, T32AI141349, and UM1AI104681, a UTHealth Presidential Award, and a University of Texas System STARS Award. B.E.M. and K.V.S. were supported in part by R21 AI133289-01A1, R21 AI143229, and R01 AI121400 from NIAID. We thank Karen Jacques-Palaz for technical assistance. Publisher Copyright: Copyright © 2021 American Society for Microbiology. All Rights Reserved.

PY - 2021/8/17

Y1 - 2021/8/17

N2 - Omadacycline (OMC) showed better in vitro potency than daptomycin (DAP) or vancomycin (VAN) against Van r, Amp r, DAP-nonsusceptible, linezolid-resistant, cfr(B) + Enterococcus faecium strains. In a mouse peritonitis model, OMC also showed significantly better animal survival during the study and at its end than DAP or VAN with these E. faecium strains. However, OMC, DAP, and VAN showed comparable in vitro and in vivo efficacies against a non-vancomycin-resistant, tetracycline-resistant, DAP-susceptible E. faecium strain.

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KW - Peritonitis/drug therapy

KW - Mice

KW - Gram-Positive Bacterial Infections/drug therapy

KW - Anti-Bacterial Agents/pharmacology

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ER -

Efficacy of omadacycline against multidrug-resistant enterococcus faecium Strains in a Mouse Peritonitis Model

Abstract

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