Efficacy of omadacycline against multidrug-resistant enterococcus faecium Strains in a Mouse Peritonitis Model

Kavindra V. Singh, Cesar A. Arias, Barbara E. Murray

Research output: Contribution to journalArticlepeer-review

Abstract

Omadacycline (OMC) showed better in vitro potency than daptomycin (DAP) or vancomycin (VAN) against Vanr, Ampr, DAP-nonsusceptible, linezolid-resistant, cfr(B)1 Enterococcus faecium strains. In a mouse peritonitis model, OMC also showed significantly better animal survival during the study and at its end than DAP or VAN with these E. faecium strains. However, OMC, DAP, and VAN showed comparable in vitro and in vivo efficacies against a non-vancomycin-resistant, tetracycline-resistant, DAP-susceptible E. faecium strain.

Original languageEnglish (US)
Article number00709
JournalAntimicrobial Agents and Chemotherapy
Volume65
Issue number9
DOIs
StatePublished - Sep 2021

Keywords

  • E. faecium
  • Mouse peritonitis
  • Omadacycline

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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