Abstract
In a mouse urinary tract infection model, omadacycline (OMC) was comparable to gentamicin and better than ciprofloxacin (CIP) against a tetracycline-susceptible (TET-S), CIP-resistant (CIP-R) Escherichia coli strain. Gentamicin showed better efficacy than OMC against a TET-R, CIP-R E. coli strain, and OMC again showed better efficacy than CIP against this strain. OMC may warrant further study as a potential option for urinary tract infection treatment against CIP-R E. coli strains.
| Original language | English (US) |
|---|---|
| Article number | e00269-21 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 65 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2021 |
Keywords
- Escherichia coli
- Mouse UTI
- Omadacycline
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases
Fingerprint
Dive into the research topics of 'Efficacy of omadacycline against escherichia coli in a mouse urinary tract infection model'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS