Efficacy of omadacycline against escherichia coli in a mouse urinary tract infection model

Kavindra V. Singh, Barbara E. Murray

Research output: Contribution to journalArticlepeer-review

Abstract

In a mouse urinary tract infection model, omadacycline (OMC) was comparable to gentamicin and better than ciprofloxacin (CIP) against a tetracycline-susceptible (TET-S), CIP-resistant (CIP-R) Escherichia coli strain. Gentamicin showed better efficacy than OMC against a TET-R, CIP-R E. coli strain, and OMC again showed better efficacy than CIP against this strain. OMC may warrant further study as a potential option for urinary tract infection treatment against CIP-R E. coli strains.

Original languageEnglish (US)
Article numbere00269-21
JournalAntimicrobial Agents and Chemotherapy
Volume65
Issue number7
DOIs
StatePublished - Jul 2021

Keywords

  • Escherichia coli
  • Mouse UTI
  • Omadacycline

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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