Abstract
We evaluated ceftobiprole against the well-characterized Enterococcus faecalis strain OG1RF (with and without the β-lactamase [Bla] plasmid pBEM10) in a murine urinary tract infection (UTI) model. Ceftobiprole was equally effective for Bla+ and Bla- OG1 strains, while ampicillin was moderately to markedly (depending on the inoculum) less effective against Bla+ than Bla- OG1 strains. These data illustrate an in vivo effect on ampicillin of Bla production by E. faecalis and the stability and efficacy of ceftobiprole in experimental UTI.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3457-3460 |
| Number of pages | 4 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 56 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 2012 |
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases
Divisions
- Infectious Disease
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