Efficacy and safety of steroid therapy for posttransplant hyperbilirubinemia caused by early allograft dysfunction: A randomized controlled trial

Jie Yang, Lei Yang, Linwei Wu, Qiang Zhao, Maogen Chen, Xiaoshun He

Research output: Contribution to journalArticle

Abstract

Background: Hyperbilirubinemia is a common event that occurs after liver transplantation. Hyperbilirubinemia is usually caused by early allograft dysfunction. Glucocorticoid is widely used for immunosuppression, but few studies have analyzed the effects of steroid therapy on posttransplantation hyperbilirubinemia. The aim of this study was to assess whether glucocorticoid was beneficial in treating hyperbilirubinemia caused by early allograft dysfunction. Material/Methods: Patients with postoperative hyperbilirubinemia (those with conditions such as biliary complications and rejections were excluded) were randomly assigned, in a 2: 1 ratio, to the steroid and control groups. Patients in the steroid group were treated with glucocorticoid combined with ursodeoxycholic acid, whereas patients in the control group were only treated with ursodeoxycholic acid. The primary endpoint was decrease in bilirubin and the secondary endpoint was safety. Results: From 1 st June 2016 to 30 th April 2018, 40 patients were enrolled into the steroid group, and 20 were enrolled into the control group. Donor, recipient, and operative data were similar between the 2 groups. The decrease in bilirubin levels in the steroid group was significantly greater than that in the control group on the first day after the intervention was finished (9.25±1.30 mg/dL vs. 3.11±1.45 mg/dL, p=0.005), and after 2 weeks (15.01±1.20 mg/dL vs. 8.88±1.98 mg/dL, p=0.007). The steroid group did not have a higher complication rate but it did have a shorter postoperative hospital stay than in the control group. Conclusions: Low-dose steroid therapy was effective and safe for treating hyperbilirubinemia caused by early graft dysfunction, and it improved liver function.

Original languageEnglish (US)
Pages (from-to)1936-1944
Number of pages9
JournalMedical Science Monitor
Volume25
DOIs
StatePublished - 2019

Keywords

  • Hyperbilirubinemia
  • Liver Transplantation
  • Methylprednisolone
  • Primary Graft Dysfunction

ASJC Scopus subject areas

  • Medicine(all)

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