Effects on serum glucose and lipids in chronic exposure to lanthanum chloride in rat

Tian Cheng Wang, Xiao He, Zhi Yong Zhang, Guang Jia, Xiang Wang, Hui Qi Shen, Yu Liang Zhao

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

OBJECTIVE: To explore the effects of serum glucose and lipids by on chronically lanthanum exposure in rat. METHODS: The Wistar rats were treated with oral exposure dose 0.1, 2 and 40 mg/kg of lanthanum chloride (LaCl(3)) respectively, after 90 days the rats were sacrificed and the blood was collected for measuring the glycosylated hemoglobin A (HbA1c), the serum was used for measuring glucose, total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) levels. RESULTS: There were no any differences among the control and 3 dose LaCl(3) exposed rats on the blood HbA1c and serum Glu, TG and LDL-C levels (P > 0.05). The serum TC in 0.1 and 2 mg/kg LaCl(3) dose group rats were (1.38 +/- 0.14) mmol/L and (1.37 +/- 0.26) mmol/L respectively. It was lower than that of the controls (1.57 +/- 0.14) mmol/L significantly (P < 0.05), the serum HDL-C in 0.1 mg/kg dose group rats was (0.79 +/- 0.12) mmol/L and obviously lower than that of control group rats (0.93 +/- 0.10) mmol/L (P < 0.05). CONCLUSION: 0.1 - 40 mg/kg LaCl(3) chronically exposed have not greater effect on serum glucose, TG and LDL-C levels in rats, but the lower dose LaCl(3) chronic exposure might cause serum TC and HLD-C level decreasing.

Original languageEnglish (US)
Pages (from-to)419-421
Number of pages3
JournalZhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
Volume40
Issue number6
StatePublished - Nov 2006

ASJC Scopus subject areas

  • Medicine(all)

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