Effects of vitamin D on macrophages and myeloid-derived suppressor cells (MDSCs) hyperinflammatory response in the lungs of COVID-19 patients

Malgorzata Kloc, Rafik M. Ghobrial, Agnieszka Lipińska-Opałka, Agata Wawrzyniak, Robert Zdanowski, Boleslaw Kalicki, Jacek Z. Kubiak

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Vitamin D regulates homeostasis, anti-microbial response, and inflammation. The vitamin D receptors are expressed in the macrophages and other immune cells, regulating the transcription of many different genes, including those coding the anti-microbial peptides. One of the most severe complications of the SARS-CoV-2 infection is the acute respiratory distress syndrome (ARDS) caused by the hyperinflammatory response (commonly called cytokine storm) of the lung macrophages. Studies showed that Vitamin D deficiency increases the severity of the ARDS in COVID-19 infection. We discuss here how the vitamin D supplementation may influence macrophage and myeloid-derived suppressor cells (MDSCs) inflammatory response, subdue the hyperinflammatory response, and lessen the ARDS in COVID-19 patients.

Original languageEnglish (US)
Article number104259
Pages (from-to)104259
JournalCellular Immunology
Volume360
DOIs
StatePublished - Feb 2021

Keywords

  • COVID-19
  • Hyperinflammatory response
  • Macrophages
  • Myeloid-derived suppressor cells (MDSCs)
  • SARS-CoV-2
  • Vitamin D
  • Vitamin D receptor
  • COVID-19/complications
  • Receptors, Calcitriol/metabolism
  • Myeloid-Derived Suppressor Cells/immunology
  • Humans
  • Vitamin D/administration & dosage
  • Macrophages/immunology
  • Lung/immunology
  • Animals
  • Respiratory Distress Syndrome/drug therapy
  • Inflammation/drug therapy
  • Child
  • Vitamins/administration & dosage

ASJC Scopus subject areas

  • Immunology

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