TY - JOUR
T1 - Effects of Time, Dose, and Inversion Time for Acute Myocardial Infarct Size Measurements Based on Magnetic Resonance Imaging-Delayed Contrast Enhancement
AU - Wagner, Anja
AU - Mahrholdt, Heiko
AU - Thomson, Louise
AU - Hager, Stefan
AU - Meinhardt, Gabriel
AU - Rehwald, Wolfgang
AU - Parker, Michele
AU - Shah, Dipan
AU - Sechtem, Udo
AU - Kim, Raymond J.
AU - Judd, Robert M.
N1 - Funding Information:
This work was supported in part by a grant from the Robert Bosch Foundation (Dr. Mahrholdt), NIH-NHLBI RO1-HL63268 (Dr. Judd), K02-HL04394 (Dr. Judd), and RO1-HL64726 (Dr. Kim).
PY - 2006/5/16
Y1 - 2006/5/16
N2 - Objectives: This study sought to investigate the influence of time, dose, and inversion time (TI) and their interactions on myocardial infarct size measurements to establish the foundation for a standardized protocol for multicenter trials. Background: There is growing interest in using magnetic resonance imaging (MRI) infarct size measurements as an end point in clinical trials. However, no standardized protocol exists, and there are limited data concerning the effects of time, contrast agent dose, and TI. Methods: First, we determined the influence of postcontrast imaging time (5 to 40 min), contrast agent dose (0.1 vs. 0.2 mmol/kg), TI, and their interactions in an animal model (n = 14). Second, we tested whether the findings of the animal study apply to patients and are generalizable. Therefore, we retested the diagnostic window in a multicenter study. A total of 48 patients with first acute myocardial infarction (AMI) from three centers were imaged twice (5 and 30 min) after injection of 0.15 mmol/kg gadolinium diethylenetriamine-pentaacetate using an adjusted TI. Results: The animal study showed that the infarct size is independent of time and dose (p = 0.9 and p = 0.16, respectively) using an adjusted TI. Using a fixed TI, however, infarct size is a function of time and dose (p = 0.0001 and p = 0.01, respectively). The multicenter study showed that MRI 1 (16.9 ± 12% of left ventricle) was not statistically different from MRI 2 (16.4 ± 12% of left ventricle, p = NS) with no difference between sites (p = NS). Conclusions: The AMI size can be measured with MRI using a contrast dose between 0.1 and 0.2 mmol/kg and a time window of 5 to 30 min after contrast administration, provided that the TI is adjusted.
AB - Objectives: This study sought to investigate the influence of time, dose, and inversion time (TI) and their interactions on myocardial infarct size measurements to establish the foundation for a standardized protocol for multicenter trials. Background: There is growing interest in using magnetic resonance imaging (MRI) infarct size measurements as an end point in clinical trials. However, no standardized protocol exists, and there are limited data concerning the effects of time, contrast agent dose, and TI. Methods: First, we determined the influence of postcontrast imaging time (5 to 40 min), contrast agent dose (0.1 vs. 0.2 mmol/kg), TI, and their interactions in an animal model (n = 14). Second, we tested whether the findings of the animal study apply to patients and are generalizable. Therefore, we retested the diagnostic window in a multicenter study. A total of 48 patients with first acute myocardial infarction (AMI) from three centers were imaged twice (5 and 30 min) after injection of 0.15 mmol/kg gadolinium diethylenetriamine-pentaacetate using an adjusted TI. Results: The animal study showed that the infarct size is independent of time and dose (p = 0.9 and p = 0.16, respectively) using an adjusted TI. Using a fixed TI, however, infarct size is a function of time and dose (p = 0.0001 and p = 0.01, respectively). The multicenter study showed that MRI 1 (16.9 ± 12% of left ventricle) was not statistically different from MRI 2 (16.4 ± 12% of left ventricle, p = NS) with no difference between sites (p = NS). Conclusions: The AMI size can be measured with MRI using a contrast dose between 0.1 and 0.2 mmol/kg and a time window of 5 to 30 min after contrast administration, provided that the TI is adjusted.
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U2 - 10.1016/j.jacc.2006.01.059
DO - 10.1016/j.jacc.2006.01.059
M3 - Article
C2 - 16697321
AN - SCOPUS:33646236076
VL - 47
SP - 2027
EP - 2033
JO - Journal of the American College of Cardiology.
JF - Journal of the American College of Cardiology.
SN - 0735-1097
IS - 10
ER -