Effects of therapy on the 1H NMR spectrum of a human glioma line

S. Cazzaniga, S. C. Schold, H. D. Sostman, H. Cecil Charles

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Currently it is difficult to predict the efficacy of any therapeutic modality in individual patients. If it could be shown that successful therapy causes some chemical alteration in the tumor before gross alteration in size becomes radiologically visible, the therapeutic regimen could potentially be modified, sparing the patients longer trials of ineffective therapy. We used proton nuclear magnetic resonance spectroscopy to detect the presence of simple metabolites (such as lactic acid, creatine/phosphocreatine, N-acetyl aspartate, and the "choline" pool) in extracts of a human glioma grown subcutaneously in athymic (" nu nu") mice. By comparing the tumor spectra obtained from untreated mice with tumor spectra from mice treated with chemotherapy or irradiation, we have shown a significant decrease in the lactate/creatine and lactate/choline values in tumors of similar size following treatment. Such information could prove valuable as a means of monitoring tumor therapy when obtained noninvasively from spatially localized in vivo spectra.

Original languageEnglish (US)
Pages (from-to)945-950
Number of pages6
JournalMagnetic Resonance Imaging
Volume12
Issue number6
DOIs
StatePublished - 1994

Keywords

  • Hydrogen
  • NMR
  • Spectroscopy
  • Therapy

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Radiology Nuclear Medicine and imaging
  • Structural Biology
  • Clinical Biochemistry
  • Biophysics

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