Effects of sulfhydryl compounds on cancer cell lines: I: N-(2-Mercaptopropionyl)-glycine exerts antiproliferating effects and antagonizes the stimulating effect of prolactin on MCF-7 human breast cancer cells

F. M. Malamas, C. G. Thomas, T. Stefos, A. Evangelou

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The effects of prolactin (PRL) and N-(2-mercaptopropionyl)-glycine (MPG) on the growth of MCF-7 human breast cancer cells, and the influence of MPG on PRL-induced MCF-7 cell proliferation, when added simultaneously to the culture medium, were examined. Prolactin at concentrations of 200 ng/ml - 350 ng/ml enhanced the growth of MCF-7 cells, while at lower and higher concentrations its action was diminished. MPG alone at concentrations above 2 mM caused a decrease in cell proliferation. When PRL and MPG were added simultaneously to the culture medium, an inhibitory effect on PRL-induced MCF-7 cell proliferation was observed, at concentrations of MPG lower than 2 mM.

Original languageEnglish (US)
Pages (from-to)329-332
Number of pages4
JournalIn Vivo
Volume21
Issue number2
StatePublished - 2007

Keywords

  • Anticarcinogens
  • Antioxidants
  • Breast cancer
  • MCF-7
  • MPG
  • Prolactin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology
  • Cancer Research

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