Abstract
The effects of prolactin (PRL) and N-(2-mercaptopropionyl)-glycine (MPG) on the growth of MCF-7 human breast cancer cells, and the influence of MPG on PRL-induced MCF-7 cell proliferation, when added simultaneously to the culture medium, were examined. Prolactin at concentrations of 200 ng/ml - 350 ng/ml enhanced the growth of MCF-7 cells, while at lower and higher concentrations its action was diminished. MPG alone at concentrations above 2 mM caused a decrease in cell proliferation. When PRL and MPG were added simultaneously to the culture medium, an inhibitory effect on PRL-induced MCF-7 cell proliferation was observed, at concentrations of MPG lower than 2 mM.
Original language | English (US) |
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Pages (from-to) | 329-332 |
Number of pages | 4 |
Journal | In Vivo |
Volume | 21 |
Issue number | 2 |
State | Published - 2007 |
Keywords
- Anticarcinogens
- Antioxidants
- Breast cancer
- MCF-7
- MPG
- Prolactin
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology
- Cancer Research