Abstract
Subacute treatment with toluene (80-1500 p.p.m.) produces a dose-dependent reduction of affinity and increase in density of the β-adrenergic antagonist [3H]dihydroalprenolol binding sites in the frontoparietal cortex of the male rat, while the binding characteristics of α1-adrenergic ([3H]WB 4101) and α2-adrenergic ([3H]p-aminoclonidine) binding sites in the same region is unaffected by this treatment as evaluated in vitro. Therefore, it is suggested that the cortical β-adrenergic receptors are particularly vulnerable to the action of toluene in vivo. It is speculated that as a result cortical α-adrenergic neurotransmission may be altered following exposure to low concentrations of toluene, possibly related to the physico-chemical properties of toluene, leading to changes in membrane fluidity.
Original language | English (US) |
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Pages (from-to) | 307-311 |
Number of pages | 5 |
Journal | Acta Physiologica Scandinavica |
Volume | 130 |
Issue number | 2 |
DOIs | |
State | Published - 1987 |
ASJC Scopus subject areas
- Physiology