Effects of subacute treatment with toluene on cerebrocortical α and β-adrenergic receptors in the rat. Evidence for an increased number and a reduced affinity of β-adrenergic receptors

K. Fuxe, M. Martire, G. von Euler, L. F. Agnati, T. Hansson, K. Andersson, J. A. Gustafsson, A. Härfstrand

    Research output: Contribution to journalArticlepeer-review

    25 Scopus citations

    Abstract

    Subacute treatment with toluene (80-1500 p.p.m.) produces a dose-dependent reduction of affinity and increase in density of the β-adrenergic antagonist [3H]dihydroalprenolol binding sites in the frontoparietal cortex of the male rat, while the binding characteristics of α1-adrenergic ([3H]WB 4101) and α2-adrenergic ([3H]p-aminoclonidine) binding sites in the same region is unaffected by this treatment as evaluated in vitro. Therefore, it is suggested that the cortical β-adrenergic receptors are particularly vulnerable to the action of toluene in vivo. It is speculated that as a result cortical α-adrenergic neurotransmission may be altered following exposure to low concentrations of toluene, possibly related to the physico-chemical properties of toluene, leading to changes in membrane fluidity.

    Original languageEnglish (US)
    Pages (from-to)307-311
    Number of pages5
    JournalActa Physiologica Scandinavica
    Volume130
    Issue number2
    DOIs
    StatePublished - 1987

    ASJC Scopus subject areas

    • Physiology

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