Effects of subacute treatment with toluene on cerebrocortical α and β-adrenergic receptors in the rat. Evidence for an increased number and a reduced affinity of β-adrenergic receptors

K. Fuxe, M. Martire, G. von Euler, L. F. Agnati, T. Hansson, K. Andersson, Jan-Ake Gustafsson, A. Härfstrand

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Subacute treatment with toluene (80-1500 p.p.m.) produces a dose-dependent reduction of affinity and increase in density of the β-adrenergic antagonist [3H]dihydroalprenolol binding sites in the frontoparietal cortex of the male rat, while the binding characteristics of α1-adrenergic ([3H]WB 4101) and α2-adrenergic ([3H]p-aminoclonidine) binding sites in the same region is unaffected by this treatment as evaluated in vitro. Therefore, it is suggested that the cortical β-adrenergic receptors are particularly vulnerable to the action of toluene in vivo. It is speculated that as a result cortical α-adrenergic neurotransmission may be altered following exposure to low concentrations of toluene, possibly related to the physico-chemical properties of toluene, leading to changes in membrane fluidity.

Original languageEnglish (US)
Pages (from-to)307-311
Number of pages5
JournalActa Physiologica Scandinavica
Volume130
Issue number2
DOIs
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Physiology

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