Effects of subacute treatment with toluene on central monoamine receptors in the rat. Reduced affinity in [3H]5-hydroxytryptamine binding sites and in [3H]spiperone binding sites linked to dopamine receptors

Marco F. Celani, Kjell Fuxe, Luigi F. Agnati, Kurt Andersson, Tiiu Hansson, Jan-Ake Gustafsson, Nino Battistini, Peter Eneroth

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Subacute treatment with toluene leads to a dose-related reduction of affinity in the [3H]spiperone binding sites labeling striatal dopamine (DA) receptors of the D2 type and cortical [3H] 5-hydroxytryptamine (5-HT)-binding sites. It is suggested that these results represent a down regulation of activity at striatal DA and cortical 5-HT synapses, since they now may operate at higher concentrations of transmitters. The reduced affinity may be caused by the physicochemical properties of toluene leading to changes in membrane fluidity and thus in the regulation of DA and 5-HT receptors in the local circuits of the striatum and the dorsal cerebral cortex.

Original languageEnglish (US)
Pages (from-to)275-281
Number of pages7
JournalToxicology Letters
Volume17
Issue number3-4
DOIs
StatePublished - Jan 1 1983

Keywords

  • 5-hydroxytryptamine
  • dopamine
  • receptors
  • Toluene

ASJC Scopus subject areas

  • Toxicology

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