Effects of somatostatin and a somatostatin agonist on diet-induced pancreatitis in mice

H. Degertekin; A. Ertan; K. Akdamar; R. Yates; I. Chen; D. H. Coy; A. Arimura

doi:10.1016/0196-9781(85)90457-7

Effects of somatostatin and a somatostatin agonist on diet-induced pancreatitis in mice

H. Degertekin, A. Ertan, K. Akdamar, R. Yates, I. Chen, D. H. Coy, A. Arimura

Houston Methodist

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

We examined the effects of somatostatin-14 and the potent somatostatin agonist (N-acetyl-[Des(Ala¹, Gly²),p-Cl-Phe⁶,D-Trp⁸]-somatostatin amide) on choline deficient, ethionine enrichèd diet (CDED)-induced acute pancreatitis in mice. Serum amylase determinations were performed, and specimens from the pancreas were examined by light and electron microscopy. No significant beneficial effects of somatostatin or its agonist were found in this model of acute pancreatitis.

Original language	English (US)
Pages (from-to)	1245-1247
Number of pages	3
Journal	Peptides
Volume	6
Issue number	6
DOIs	https://doi.org/10.1016/0196-9781(85)90457-7
State	Published - 1985

Keywords

Diet-induced acute pancreatitis
Somatostatin
Somatostatin agonist

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Physiology
Endocrinology
Biochemistry

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10.1016/0196-9781(85)90457-7

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title = "Effects of somatostatin and a somatostatin agonist on diet-induced pancreatitis in mice",

abstract = "We examined the effects of somatostatin-14 and the potent somatostatin agonist (N-acetyl-[Des(Ala1, Gly2),p-Cl-Phe6,D-Trp8]-somatostatin amide) on choline deficient, ethionine enrich{\`e}d diet (CDED)-induced acute pancreatitis in mice. Serum amylase determinations were performed, and specimens from the pancreas were examined by light and electron microscopy. No significant beneficial effects of somatostatin or its agonist were found in this model of acute pancreatitis.",

keywords = "Diet-induced acute pancreatitis, Somatostatin, Somatostatin agonist",

author = "H. Degertekin and A. Ertan and K. Akdamar and R. Yates and I. Chen and Coy, \{D. H.\} and A. Arimura",

note = "Funding Information: 1This study was supported by the Gastroenterology Section Research Fund, NIH grants AM-18370, 09094, 530569 and was presented in part at the Meeting of American Pancreatic Association in Chicago, IL 1984. -'Requests for reprints should be addressed to Atilla Ertan, M.D., Tulane University School of Medicine, Section of Gastroenterology, 1430 Tulane Avenue, New Orleans, LA 70112. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.",

year = "1985",

doi = "10.1016/0196-9781(85)90457-7",

language = "English (US)",

volume = "6",

pages = "1245--1247",

journal = "Peptides",

issn = "0196-9781",

publisher = "Elsevier",

number = "6",

}

TY - JOUR

T1 - Effects of somatostatin and a somatostatin agonist on diet-induced pancreatitis in mice

AU - Degertekin, H.

AU - Ertan, A.

AU - Akdamar, K.

AU - Yates, R.

AU - Chen, I.

AU - Coy, D. H.

AU - Arimura, A.

N1 - Funding Information: 1This study was supported by the Gastroenterology Section Research Fund, NIH grants AM-18370, 09094, 530569 and was presented in part at the Meeting of American Pancreatic Association in Chicago, IL 1984. -'Requests for reprints should be addressed to Atilla Ertan, M.D., Tulane University School of Medicine, Section of Gastroenterology, 1430 Tulane Avenue, New Orleans, LA 70112. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.

PY - 1985

Y1 - 1985

N2 - We examined the effects of somatostatin-14 and the potent somatostatin agonist (N-acetyl-[Des(Ala1, Gly2),p-Cl-Phe6,D-Trp8]-somatostatin amide) on choline deficient, ethionine enrichèd diet (CDED)-induced acute pancreatitis in mice. Serum amylase determinations were performed, and specimens from the pancreas were examined by light and electron microscopy. No significant beneficial effects of somatostatin or its agonist were found in this model of acute pancreatitis.

AB - We examined the effects of somatostatin-14 and the potent somatostatin agonist (N-acetyl-[Des(Ala1, Gly2),p-Cl-Phe6,D-Trp8]-somatostatin amide) on choline deficient, ethionine enrichèd diet (CDED)-induced acute pancreatitis in mice. Serum amylase determinations were performed, and specimens from the pancreas were examined by light and electron microscopy. No significant beneficial effects of somatostatin or its agonist were found in this model of acute pancreatitis.

KW - Diet-induced acute pancreatitis

KW - Somatostatin

KW - Somatostatin agonist

UR - https://www.scopus.com/pages/publications/0022372757

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U2 - 10.1016/0196-9781(85)90457-7

DO - 10.1016/0196-9781(85)90457-7

M3 - Article

C2 - 2422635

AN - SCOPUS:0022372757

SN - 0196-9781

VL - 6

SP - 1245

EP - 1247

JO - Peptides

JF - Peptides

IS - 6

ER -

Effects of somatostatin and a somatostatin agonist on diet-induced pancreatitis in mice

Abstract

Keywords

ASJC Scopus subject areas

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