We examined the effects of somatostatin-14 and the potent somatostatin agonist (N-acetyl-[Des(Ala1, Gly2),p-Cl-Phe6,D-Trp8]-somatostatin amide) on choline deficient, ethionine enrichèd diet (CDED)-induced acute pancreatitis in mice. Serum amylase determinations were performed, and specimens from the pancreas were examined by light and electron microscopy. No significant beneficial effects of somatostatin or its agonist were found in this model of acute pancreatitis.
- Diet-induced acute pancreatitis
- Somatostatin agonist
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience