TY - JOUR
T1 - Effects of somatostatin and a somatostatin agonist on diet-induced pancreatitis in mice
AU - Degertekin, H.
AU - Ertan, A.
AU - Akdamar, K.
AU - Yates, R.
AU - Chen, I.
AU - Coy, D. H.
AU - Arimura, A.
N1 - Funding Information:
1This study was supported by the Gastroenterology Section Research Fund, NIH grants AM-18370, 09094, 530569 and was presented in part at the Meeting of American Pancreatic Association in Chicago, IL 1984. -'Requests for reprints should be addressed to Atilla Ertan, M.D., Tulane University School of Medicine, Section of Gastroenterology, 1430 Tulane Avenue, New Orleans, LA 70112.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1985
Y1 - 1985
N2 - We examined the effects of somatostatin-14 and the potent somatostatin agonist (N-acetyl-[Des(Ala1, Gly2),p-Cl-Phe6,D-Trp8]-somatostatin amide) on choline deficient, ethionine enrichèd diet (CDED)-induced acute pancreatitis in mice. Serum amylase determinations were performed, and specimens from the pancreas were examined by light and electron microscopy. No significant beneficial effects of somatostatin or its agonist were found in this model of acute pancreatitis.
AB - We examined the effects of somatostatin-14 and the potent somatostatin agonist (N-acetyl-[Des(Ala1, Gly2),p-Cl-Phe6,D-Trp8]-somatostatin amide) on choline deficient, ethionine enrichèd diet (CDED)-induced acute pancreatitis in mice. Serum amylase determinations were performed, and specimens from the pancreas were examined by light and electron microscopy. No significant beneficial effects of somatostatin or its agonist were found in this model of acute pancreatitis.
KW - Diet-induced acute pancreatitis
KW - Somatostatin
KW - Somatostatin agonist
UR - http://www.scopus.com/inward/record.url?scp=0022372757&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022372757&partnerID=8YFLogxK
U2 - 10.1016/0196-9781(85)90457-7
DO - 10.1016/0196-9781(85)90457-7
M3 - Article
C2 - 2422635
AN - SCOPUS:0022372757
VL - 6
SP - 1245
EP - 1247
JO - Peptides
JF - Peptides
SN - 0196-9781
IS - 6
ER -