Effects of somatostatin and a somatostatin agonist on diet-induced pancreatitis in mice

H. Degertekin; A. Ertan; K. Akdamar; R. Yates; I. Chen; D. H. Coy; A. Arimura

doi:10.1016/0196-9781(85)90457-7

Effects of somatostatin and a somatostatin agonist on diet-induced pancreatitis in mice

H. Degertekin, A. Ertan, K. Akdamar, R. Yates, I. Chen, D. H. Coy, A. Arimura

Research output: Contribution to journal › Article

19 Scopus citations

Abstract

We examined the effects of somatostatin-14 and the potent somatostatin agonist (N-acetyl-[Des(Ala¹, Gly²),p-Cl-Phe⁶,D-Trp⁸]-somatostatin amide) on choline deficient, ethionine enrichèd diet (CDED)-induced acute pancreatitis in mice. Serum amylase determinations were performed, and specimens from the pancreas were examined by light and electron microscopy. No significant beneficial effects of somatostatin or its agonist were found in this model of acute pancreatitis.

Original language	English (US)
Pages (from-to)	1245-1247
Number of pages	3
Journal	Peptides
Volume	6
Issue number	6
DOIs	https://doi.org/10.1016/0196-9781(85)90457-7
State	Published - 1985
Externally published	Yes

Keywords

Diet-induced acute pancreatitis
Somatostatin
Somatostatin agonist

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Physiology
Endocrinology
Biochemistry

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abstract = "We examined the effects of somatostatin-14 and the potent somatostatin agonist (N-acetyl-[Des(Ala1, Gly2),p-Cl-Phe6,D-Trp8]-somatostatin amide) on choline deficient, ethionine enrich{\`e}d diet (CDED)-induced acute pancreatitis in mice. Serum amylase determinations were performed, and specimens from the pancreas were examined by light and electron microscopy. No significant beneficial effects of somatostatin or its agonist were found in this model of acute pancreatitis.",

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T1 - Effects of somatostatin and a somatostatin agonist on diet-induced pancreatitis in mice

AU - Degertekin, H.

AU - Ertan, A.

AU - Akdamar, K.

AU - Yates, R.

AU - Chen, I.

AU - Coy, D. H.

AU - Arimura, A.

PY - 1985

Y1 - 1985

N2 - We examined the effects of somatostatin-14 and the potent somatostatin agonist (N-acetyl-[Des(Ala1, Gly2),p-Cl-Phe6,D-Trp8]-somatostatin amide) on choline deficient, ethionine enrichèd diet (CDED)-induced acute pancreatitis in mice. Serum amylase determinations were performed, and specimens from the pancreas were examined by light and electron microscopy. No significant beneficial effects of somatostatin or its agonist were found in this model of acute pancreatitis.

AB - We examined the effects of somatostatin-14 and the potent somatostatin agonist (N-acetyl-[Des(Ala1, Gly2),p-Cl-Phe6,D-Trp8]-somatostatin amide) on choline deficient, ethionine enrichèd diet (CDED)-induced acute pancreatitis in mice. Serum amylase determinations were performed, and specimens from the pancreas were examined by light and electron microscopy. No significant beneficial effects of somatostatin or its agonist were found in this model of acute pancreatitis.

KW - Diet-induced acute pancreatitis

KW - Somatostatin

KW - Somatostatin agonist

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