Effects of somatostatin and a somatostatin agonist on diet-induced pancreatitis in mice

H. Degertekin, A. Ertan, K. Akdamar, R. Yates, I. Chen, D. H. Coy, A. Arimura

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

We examined the effects of somatostatin-14 and the potent somatostatin agonist (N-acetyl-[Des(Ala1, Gly2),p-Cl-Phe6,D-Trp8]-somatostatin amide) on choline deficient, ethionine enrichèd diet (CDED)-induced acute pancreatitis in mice. Serum amylase determinations were performed, and specimens from the pancreas were examined by light and electron microscopy. No significant beneficial effects of somatostatin or its agonist were found in this model of acute pancreatitis.

Original languageEnglish (US)
Pages (from-to)1245-1247
Number of pages3
JournalPeptides
Volume6
Issue number6
DOIs
StatePublished - 1985
Externally publishedYes

Keywords

  • Diet-induced acute pancreatitis
  • Somatostatin
  • Somatostatin agonist

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Physiology
  • Endocrinology
  • Biochemistry

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