@inproceedings{35cf3c7d721144c6a904744980f01b59,
title = "Effects of scar architecture on cardiac strains in myocardial infarction",
abstract = "Myocardial infarction (MI) alters the structural and mechanical behavior of the heart and causes impairment in organ-level function. This study employs an in-silico biventricular heart model developed from high-resolution magnetic resonance imaging (MRI) to simulate an infarcted heart and examine the effects of infarct size and fiber alignment on regional cardiac mechanics. The results show that both increasing the scar size as well as increasing the level of fiber disarray in the infarct have a negative effect on average fiber strains. Increased scar size from 30% to 70% (of the left ventricle myocardial volume) reduced contractile strains in remote tissue by nearly 20%, whereas contractile strain was reduced by 6% as a result of introducing a 50% fiber disarray in the infarct region. This research highlights the importance of characterizing scar properties to improve understanding of post-MI remodeling and to inform therapeutic strategies aimed at preserving or restoring heart function.",
keywords = "Cardiac Mechanics, Computational Biomechanics, In-Silico Modeling, Myocardial Infarction",
author = "Vahid Naeini and Peighambari, {Seyed Babak} and Mehdi, {Rana Raza} and Mendiola, {Emilio A.} and Tanmay Mukherjee and Reza Avazmohammadi",
note = "Publisher Copyright: {\textcopyright} 2025 SPIE; Medical Imaging 2025: Image-Guided Procedures, Robotic Interventions, and Modeling ; Conference date: 17-02-2025 Through 20-02-2025",
year = "2025",
doi = "10.1117/12.3047508",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Rettmann, {Maryam E.} and Siewerdsen, {Jeffrey H.}",
booktitle = "Medical Imaging 2025",
address = "United States",
}