Effects of physical conditioning on fibrinolytic variables and fibrinogen in young and old healthy adults

John R. Stratton, Wayne L. Chandler, Robert S. Schwartz, Manuel D. Cerqueira, Wayne C. Levy, Steven E. Kahn, Valerie G. Larson, Kevin C. Cain, James C. Beard, Itamar B. Abrass

Research output: Contribution to journalArticlepeer-review

238 Scopus citations


Background. The effects of 6 months of intensive endurance exercise training on resting tissue-type plasminogen activator (t-PA) activity, plasminogen activator inhibitor type 1 (PAI-1) activity, t-PA antigen, and fibrinogen were studied in 10 young (24-30 years) and in 13 old male subjects (60-82 years). Methods and Results. After training, maximum oxygen consumption was increased in the young group by 18% (44.9±5.0 to 52.9±6.6 ml/kg/min, p<0.001), whereas it was increased in the old group by 22% (29.0±4.2 to 35.5±3.6 ml/kg/min, p<0.001). The young group had no significant changes in any of the measured variables, whereas the old group had a 39% increase in t-PA activity (0.82±0.47 to 1.14±0.42 IU/ml, p<0.03), a 141% increase in the percentage of t-PA in the active form (11.1±7.7 to 26.8±15.1%, p<0.01), a 58% decrease in PAI-1 activity (8.4±4.9 to 3.5±1.7 AU/ml, p<0.01), and a 13% decrease in fibrinogen (3.57±0.79 to 3.11±0.52 g/l, p<0.01). Conclusions. We conclude that intensive exercise training enhances resting t-PA activity and reduces fibrinogen and PAI-1 activity in older men. These effects are potential mechanisms by which habitual physical activity might reduce the risk of cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)1692-1697
Number of pages6
Issue number5
StatePublished - May 1991


  • Fibrinogen
  • Fibrinolysis
  • Thrombosis

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Effects of physical conditioning on fibrinolytic variables and fibrinogen in young and old healthy adults'. Together they form a unique fingerprint.

Cite this