Abstract
Methylglyoxal (MG) has been shown to have a depolarizing effect on the giant interneurones of the isolated 6th abdominal ganglion of the cockroach. This effect of MG was inhibited by concentrations of nicotine, d-tubocurarine and physostigmine which blocked transmission at the cholinergic cercal nerve-giant interneurone synapse. MG (5 x 10-5 to 5 x 10-4 M) produced concentration-dependent contractures of the isolated frog rectus abdominis muscle which were inhibited by d-tubocurarine (10-4 M) and phystostigmine (10-6 M). MG enhanced the action of acetylcholine and inhibited KCl-evoked contractures whereas it had no effect on the response to carbachol. It is concluded that MG appears to act as a cholinomimetic in both the peripheral and central nervous system.
Original language | English (US) |
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Pages (from-to) | 46-50 |
Number of pages | 5 |
Journal | Archives of Toxicology |
Volume | 59 |
Issue number | SUPPL. 9 |
State | Published - Jan 1 1986 |
ASJC Scopus subject areas
- Toxicology
- Health, Toxicology and Mutagenesis