Effects of methylglyoxal on central and peripheral cholinergic responses

Mark Davies; P. L. Chambers; M. J. Rowan

Effects of methylglyoxal on central and peripheral cholinergic responses

Mark Davies, P. L. Chambers, M. J. Rowan

Houston Methodist

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Methylglyoxal (MG) has been shown to have a depolarizing effect on the giant interneurones of the isolated 6th abdominal ganglion of the cockroach. This effect of MG was inhibited by concentrations of nicotine, d-tubocurarine and physostigmine which blocked transmission at the cholinergic cercal nerve-giant interneurone synapse. MG (5 x 10^-5 to 5 x 10^-4 M) produced concentration-dependent contractures of the isolated frog rectus abdominis muscle which were inhibited by d-tubocurarine (10^-4 M) and phystostigmine (10^-6 M). MG enhanced the action of acetylcholine and inhibited KCl-evoked contractures whereas it had no effect on the response to carbachol. It is concluded that MG appears to act as a cholinomimetic in both the peripheral and central nervous system.

Original language	English (US)
Pages (from-to)	46-50
Number of pages	5
Journal	Archives of Toxicology
Volume	59
Issue number	SUPPL. 9
State	Published - Jan 1 1986

ASJC Scopus subject areas

Toxicology
Health, Toxicology and Mutagenesis

Cite this

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N2 - Methylglyoxal (MG) has been shown to have a depolarizing effect on the giant interneurones of the isolated 6th abdominal ganglion of the cockroach. This effect of MG was inhibited by concentrations of nicotine, d-tubocurarine and physostigmine which blocked transmission at the cholinergic cercal nerve-giant interneurone synapse. MG (5 x 10-5 to 5 x 10-4 M) produced concentration-dependent contractures of the isolated frog rectus abdominis muscle which were inhibited by d-tubocurarine (10-4 M) and phystostigmine (10-6 M). MG enhanced the action of acetylcholine and inhibited KCl-evoked contractures whereas it had no effect on the response to carbachol. It is concluded that MG appears to act as a cholinomimetic in both the peripheral and central nervous system.

AB - Methylglyoxal (MG) has been shown to have a depolarizing effect on the giant interneurones of the isolated 6th abdominal ganglion of the cockroach. This effect of MG was inhibited by concentrations of nicotine, d-tubocurarine and physostigmine which blocked transmission at the cholinergic cercal nerve-giant interneurone synapse. MG (5 x 10-5 to 5 x 10-4 M) produced concentration-dependent contractures of the isolated frog rectus abdominis muscle which were inhibited by d-tubocurarine (10-4 M) and phystostigmine (10-6 M). MG enhanced the action of acetylcholine and inhibited KCl-evoked contractures whereas it had no effect on the response to carbachol. It is concluded that MG appears to act as a cholinomimetic in both the peripheral and central nervous system.

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Effects of methylglyoxal on central and peripheral cholinergic responses

Abstract

ASJC Scopus subject areas

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